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Medicine Term One > antimicrobial chemotherapy - anti fungal drugs > Flashcards

antimicrobial chemotherapy - anti fungal drugs Flashcards

1
Q

What can fungus be subdivided into

A

Yeats and filamentous fungi (moulds)

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2
Q

What is the combined form of fungus called

A

dimorphic fungi

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3
Q

What are the different classes of anti fungal drugs

A

Polyenes
Azoles
Allyamines
Echinocandins

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4
Q

How do polyenes increase the permeability of the cell wall

A

Bind to ergosterol in fungi cell wall

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5
Q

What is the reason for polyenes toxicity

A

also bind to other sterols (cholesterol) in mammalian cells

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6
Q

What are two examples of polyenes anti fungal drugs

A

amphotericin B

Nystatin

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7
Q

Is amphotericin toxic?

A

yes

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8
Q

What polyenes anti fungal drug can be available for IV use

A

amphotericin B

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9
Q

How is nystatin available

A

topic use (creams, oral, pessaries)

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10
Q

How do azoles work as an anti fungal

A

inhibit ergosterol synthesis

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11
Q

How are azoles subdivided

A

Imidazoles

triazoles

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12
Q

Name two imidazoles

A

miconazole

ketoconazole

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13
Q

Give three examples of triazoles

A

flucanozole
itraconazole
voriconazole

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14
Q

How is flucaozole given and what is it active against

A

used for oral and parenteral treatment of yeast infections

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15
Q

What is itraconazole active against

A

Yeast and filamentous fungi

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16
Q

What can treat aspergillosis

A

voriconazole and itraconazole

17
Q

What is building a resistance to fluconazole

A

resistance among some candida species

18
Q

How do allylamines work as anti fungals

A

suppress ergosterol synthesis

19
Q

what is an example of an allylamine anti fungal

A

terbinafine

20
Q

What is terabinafine primarily active against and its clinical use

A

dermatophytes

dermatophyte infections of the skin and nails e.g. athletes foot

21
Q

How does echinocandins work as an anti fungal

A

inhibit the synthesis of glucan polysaccharide

22
Q

What are the three echinocandins

A

caspofungin
mycafungin
andiulafungin

23
Q

What are ecinocandins used for

A

serious aspergillus and candida infections

Medicine Term One (59 decks)

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