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Medicine Term One > Pathogen and host: Immunity > Flashcards

Pathogen and host: Immunity Flashcards

1
Q

What capsule organism is resistant to phagocytosis

A

Strep pneumoniae

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2
Q

What organism is resistant to intracellular killing

A

Mycobacterium tuberculosis
Legionella pneumophila
Candida albicans (AIDS)

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3
Q

What is involved in monoclear phagocytic system

A

liver (clears bile to liver)
spleen (filters the blood)
lymph nodes (drains peripheral sites)

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4
Q

What is opsonisation

A

Organisms coated with antibody allowing immune system recognition,

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5
Q

In humeral response what is produced

A

antibodies (b cells)

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6
Q

In cellular response what is produced

A

T cells

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7
Q

What is an epitode

A

the part of an antigen molecule to which an antibody attaches itself

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8
Q

What does opsonisation allow

A

Increase in phagocyte efficiency

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9
Q

What are immunoglobulins

A

are the proteins with antibody activity

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10
Q

what are the 5 classes of immunoglobulins

A
  1. IgG - Gamma heavy chains
  2. IgM - Mu heavy chains
  3. IgA - Alpha heavy chains
  4. IgD - Delta heavy chains
  5. IgE - Epsilon heavy chains
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11
Q

IgA

A

Initial defence in mucosal against pathogen agents

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12
Q

IgM

A

Expressed in the surface of B-cells promoting phagocytosis and activate the complement system

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13
Q

IgE

A

Allergy and helminth infection

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14
Q

IgG

A

Moat abundant, promote phagocytosis in plasma and activate the complement system

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15
Q

What immunoglobulins are needed in compliment system

A

IgG or IgM

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16
Q

What happens to B lymphocytes when the recognise specific epitope

A

differentiate into plasma cells

17
Q

What kind of T helper cells do by lymphocytes need

A

CD4+

18
Q

Whats the most important proteins out of the 20 complement proteins

A

c1 - c9

19
Q

what specificity does;
monoclonal antibody
polyclonal antibody

A

Single epitope specificity

Multiple specificity

20
Q

What does antibody do in an infection

A

neutralises bacterial toxins
neutralises viruses (stop virus in the blood)
prevents adherence of microorganisms
Induce phagocytosis

21
Q

What does complement do to gram -

A

lysis

22
Q

What happens to complement by products

A

chemotactic, attract further WBC

23
Q

What happens in cell mediated immunity with t helper cells

A

Macrophage present antigen MCH2 to T helper cell CD4 inducing cytokines production, activating macrophages

24
Q

What does humoral immunity induce

A

inflammation

25
Q

T helper cells functions

A

Cell mediated immunity by activating macrophages

help B cells antibody response

26
Q

What happens to cytotoxic T-cells (CD8)

A

Combine with MHC1 antigen and if detect host is infected, kills the cell

Medicine Term One (59 decks)

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