Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Host and Defense COPY > Adaptive Immune Disease - German 2017 - edited from Cutler > Flashcards

Adaptive Immune Disease - German 2017 - edited from Cutler Flashcards

1
Q

Autoimmune Diseases are loss of ____ leading to hypersensitivity reactions.

A

-Tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What type of selection in B cells contribute to self-tolerance?

A

-Negative selection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What types of hypersensitivity reactions are involved in Autoimmune Diseases?

A

-Type II-Type III-Type IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

AD’s are caused by what two things?

A
  • Genetics

- Environments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

_____ subtype influences AD development.

A

-HLA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

HLA genes are associated with susceptibility in what percent of ADs?

A

50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

WhatMHC class of alleles are most frequently implicated in ADs?

A

-Class II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Grave’s disease is associated with what type of hypersensitivity?

A

-Type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Type 2 Diabetes is associated with what type of hypersensitivity?

A

-Type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Rheumatic Fever is caused by what? What type hypersensitivity is it? Why does it not last forever?

A

-Molecular mimicry
Type 2 hypersensitivity
it doesn’t last forever because T cells are not involved because it is just antibody mediated. This demonstrates T cell necessity for prolonged autoimmunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

T/F S. pyogenes cell wall shares human epitopes and that is how Rheumatic Fever is caused by Molecular mimicry

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Graves disease is associated with antibody binding that causes what to happen to the Thymus?

A

Activation of the thymus because the antibodies act as a TSH agonist and thus excessive thyroid hormone release.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

T/F If a mother has grave’s disease she can pass it during pregnancy to the baby

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What disease is associated with the destruction of normal thyroid tissue (hypothyroidism, the thyroid looks enlarged though)? What cells mediate this destruction?

A

-Hashimoto’s disease

mediated by CD4 TH1 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What type of hypersensitivity is Hashimoto’s disease associated with?

A

-Type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What disease is associated with salivary gland enlargement, Glossitis, and mouth breathing?

A

-Hypothyroidism aka Hashimoto’s disease

17
Q

What disease is associated with increased susceptibility to caries, enlargement of extra glandular thyroid tissue, and has accelerated dental eruption, burning mouth syndrome?

A

-Hyperthyroidism aka Graves’ disease

18
Q

What disease is associated with progressive destruction of the exocrine glands?

A

-Sjogren’s syndrome

19
Q

Who is Sjogren’s syndrome more prevalent in? What type of hypersensitivity is it? What are some signs of Sjogren’ts?

A

-Women
type 2 hypersensitivity
dry eyes and mouth, prominent caries, oral candidiasis

20
Q

What type of hypersensitivity is associated with systemic lupus erythematosus?

A

-Type III

21
Q

If you have mouth ulcers and plaques, deposits in blood vessels kidney and joints what disease is that associated with?

A

-Systemic lupus erythematosus

22
Q

Systemic Lupus causes deposits of antigen and epitope in what 3 places most? What is the mechanism called that leads to progressively more destruction?

A

Blood vessels, kidneys, and joints

epitope spreading which is when proteins/eptiopes that are associated with each other all get tagged as foreign because they are a complex.

23
Q

T/F SLE leads to a loss of tolerance

A

True

24
Q

T/F Intermolecular epitope spreading is different proteins being targeted from one initial protein while intramolecular is one small conserved region of a protein shares an epitope with a pathogen and now an entire protein can be targeted.

A

True

25
Q

What type of hypersensitivity is celiac disease?

A

-Type IV

26
Q

T/F Thymic involution (which comes with aging) is tied to increase AD incidence

A

True

27
Q

Type I diabetes is what type of hypersensitivity reaction? What are the 4 oral manifestations?

A
  • Type IV
  • Sweet breath
  • Impaired wound healing
  • Altered saliva composition
  • Reduced salivary flow
28
Q

In Type I diabetes autoimmunity what kills the Beta cells?

A

CD4 and CD8 T cells

29
Q

T/F trauma can cause autoimmunity

A

true

30
Q

type 2 hypersensitivity caused ADs can have antagonistic or agonistic antibodies T/F

A

True

31
Q

In periodontitis with P. gingivalis, the bacteria citrulinate host or bacterial proteins and the body associates citrullination with the bacteria and so what happens in the future?

A

any tissue that is citrullinated is destroyed.

Host and Defense COPY (81 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions