HIV - Winkler 2017 - edited from Cutler

Question 1

What type of HIV may be less virulent and have a longer latency period?

Answer 1

-HIV-2

Question 2

What type of test can detect either one or both types of HIV?

Answer 2

-EIA

Question 3

Worldwide what is the prominant type of HIV?

Answer 3

-HIV-1

Question 4

What are the main cells infected by HIV?

Answer 4

-CD4 T cells (main one)-Monocytes-Macrophages

Question 5

If you give a mother what HIV treating drug will it almost completely eliminate the chance of the baby getting HIV from mom? This was the first effective HIV drug

Answer 5

-AZT (Azidothymidine)

Question 6

What are the six steps in HIV life cycle?

Answer 6

-Binding-Fusion-Reverse transcription-Integration-Assembly-Budding

Question 7

In the current HAART (cART) therapy how many drugs are combined? They usually have one “strong drug” what are the options for that?

Answer 7

-3 or more drugsNNRTIProtease InhibitorINSTI or II

Question 8

In the cART therapy combination how many nucleoside analogue RT inhibitors are used?

Answer 8

-Usually two

Question 9

T/F HIV can now be considered a chronic infection

Answer 9

True

Question 10

Do successfully treated HIV patients live as long as an uninfected individuals?

Answer 10

-No it is shorter than normal but longer than not being treated at all

Question 11

With HIV drugs have a hepatotoxicity side effect?

Answer 11

-NNRTI-PI

Question 12

What are four dental concerns that deal with the hepatotoxicity effects of HIV drugs?

Answer 12

-Local anesthetics-antibiotics-Pain Killers-Antifungals (because these are metabolized in the liver)

Question 13

What HIV drug are Hyper lipidemia and osteonecrosis associated with?

Answer 13

-PI (Protease Inhibitors)

Question 14

T/F Immunocrompromised individuals have a greater risk for post operative complications

Answer 14

True according to the book, false according to winkler… pick your poison

Question 15

T/F HAART therapy has reduced the amount of oral lesions caused by HIV

Answer 15

True

Question 16

With HAARt therapy what has happened with salivary gland disease and oral warts?

Answer 16

-Increases in both

Question 17

What are oral manifestations of HIV indicative of?

Answer 17

-Disease progression

Question 18

What CD4 count levels should you be worried about in HIV pts?

Answer 18

-Less than 200

Question 19

T/F Hairy leukoplakia is not associated with HIV

Answer 19

False-It is

Question 20

T/F Oral candidiasis has declined in HIV patients since HAART therapy but it is still present

Answer 20

True

Question 21

Has Kapsoi’s sarcoma increased or decreased in HIV pts on HAART therapy

Answer 21

Decreased

Question 22

Has pappilomas increased or decreased in HIV pts on HAART therapy?

Answer 22

-Increased