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Flashcards in 6.11 Transforming cells Deck (54)
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31

ST abl

tyrosine kinase translocation

32

nuclear regulatory protein

myc, L-myc, N-myc, fos, jun

33

NucReg myc and APC casset

transcription, changed by translocation/amplification

34

cell cycle regulation

Cyclin D, CDK4

35

CellCycle Cyclin D

Cyclin, translocation/amplification

36

CellCycle CDK4

CD kinase, amplification/point muation

37

how CDK and Cyclins work together

CDK is always present, cyclin is synthesized to activate CDK

38

major cyclins in G1-S

D and E

39

major CDK in G1 to S

2, 4, 6

40

inhibitors of CDK 4 and 6

p21, 27, 57, 26-19

41

action of activated CDK 2, 4, 6

phosphorylates Rb which releases E2F family of transcription factors, allowing cell to proceed from G1 to S

42

Cyclin D binds

CDK 4/6 for G1 to S passage

43

Cyclin E binds

CDK 2 for G1 to S passage

44

Cyclin A binds

CDK 2/1 for S to G2 passage

45

Cyclin B finds

CDK 1 for passage from G2 to M

46

CDK4 inhibitors

p 15, 16, 18, 19

47

CDK 6,2,1 inhibitors

p 21, 27, 57

48

CIP/KIP family CDK inhibitors

p27, p16

49

p21 is induced by

p53

50

p27 is induced by

TGFbeta and other suppressors

51

INK4/ARF family CDP inhibitors

p16, p14

52

p16 inhibits by

binding cylinD-CDK4 promoting Rb inhibition

53

p14 inhibits by

increasing p53 by inhibiting MDM2

54

p53

tumor suppressor, causes cell cycle arrest and apoptosis by inducing p21 and BAX; inhibited by MDM2