Flashcards in 7/22 Deck (53)
what cancers does Lynch Syndrome give you, and what genes?
what cancers does FAP give you, and what gene?
desmoids and osteomas
what cancers does VHL give you and and what gene?
renal clear cell carcinoma
what cancers does Li Fraumeni syndrome give you, and what gene?
which nerves carry the afferent and efferent limbs of the carotid sinus reflex
efferent: parasympathetic vagus
which molecule recognizes stop codons
Releasing Factor 1
what are efficacy and potency of drugs
efficacy is the "vertical" measure- % of maximal effect
potency is the "horizontal" measure-what doses are required to reach the same height on the graph
what is Sirolimus's MOA
inhibits mTOR, which blocks IL-2 and prevents cell cycle progression and lymphocyte proliferation
what can cause a dilated coronary sinus
leading to elevated Right heart pressures
which pharyngeal pouch does the thymus come from
3rd pharyngeal pouch (with the inferior parathyroids)
what TB drug has to be processed by mycobacterial catalase peroxidase in order to be activated
what do you classically on crohn's histology
noncaseating granulomas and transmural inflammation
which renal pathology causes selective loss of albumin in urine
minimal change disease
caused by loss of anion properties of the glomerular BM
which disease has autoimmune destruction of intrahepatic, interlobular bile ducts by granulomatous inflammation
typically presents w/ pruritus and fatigue in middle aged F
which lung exposure die you pleural thickening and calcified lesions on diaphragm etc?
what 2 lab values will be elevated in a neural tube defect
AchE and AFP
what does dermatomyositis have a strong association with
malignancy, including lung, colorectal, and ovarian cancers
what is apolipoprotein E4 genotype associated with
what are the 3 gene mutations associated with early-onset Alzheimer's
APP (chromosome 21)
what disease presents with tinnitus, vertigo, and sensorineural hearing loss
what causes Meniere's disease
increased pressure and volume of endolymph
what are occupational exposures to rubber, aromatic dyes, textiles, and leather a risk factor for
transitional cell carcinoma of the bladder
what cells are neurofibromas and NF's associated with
neural crest cells
what are tazobactam, clavulanate, and sulbactam MOA's?
prevent excessive destruction of the antibiotic they're paired with
what vitamin can help treat measles
what will constriction of efferent arteriole do to RPF and FF?
increase FF (by increasing GFR from back-up of fluid and increase of hydrostatic pressure)
what is Trastuzumab's MOA?
monoclonal antibody that binds to a portion of HER2 and prevents activation of tyrosine kinase, which will promote apoptosis
when do you give an ER modulator vs an aromatase inhibitor for breast cancer
what is the buzzword for tissue transglutaminase