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Flashcards in 7/26 Deck (52)
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1

what is a possible complication of taking erythropoietin-stimulating meds?

worsening HTN
thromboembolic events (more viscosity)

2

what can valproate do to pregnant women

can cause neural tube defects during the vulnerable period (4th week of gestation), often before pts discover they're pregnant

3

which lab value is a measure of the potency of an inhaled anesthetic

MAC

potency is inversely proportional to the MAC: the lower the MAC, the more potent a drug

4

which drug that can be prescribed for HTN can cause peripheral edema

dihydropyridine CCBs (amlodipine)

5

what should HIV pts with CD4 counts <50 be administered prophylactically to prevent MAC?

Azithromycin

(it might hint at MAC with nonspecific symptoms but a bug that grows well higher temperatures, like 41 C)

6

which G protein couple receptors increase and decrease insulin secretion, respectively?

increase insulin:
Muscarinic M3 (Gq)
Glucagon (Gs/Gq)
beta-2 adrenergic (Gs)
glucagon-like peptide-1 (Gs)

decrease insulin:
alpha-2 (Gi)
somatostatin 2 (Gi)

7

which drug treats trigeminal myalgia but can also give you pancytopenia/bone marrow suppression

carbamazepine

it inhibits high-frequency Na channels

8

what enzyme degrades 6-mercaptopurine

Xanthine oxidase

9

what is vincristine's main side effect

neurotoxicity (peripheral neuropathy)

10

which drug preferentially binds to rapidly depolarizing and ischemic ventricular myocardial fibers, with minimal effect on normal ventricular myocardium

class 1B antiarrhythmics (Lidocaine)-
they're highly efficacious in inhibiting ischemia-induced ventricular arrhythmias


(amiodarone is 1st line though)

11

which drugs are the short vs long acting sulfonylureas

short: glipizide

long: glyburide, glimepiride

12

what 3 drugs do you commonly use for medical abortion

mifepristone is a progesterone antagonist (and a glucocorticoid antagonist)

misoprostol is a PGE1 agonist


methotrexate is a folic acid antagonist

13

what are you most concerned about with lamotrigine

toxic epidermal necrolysis / SJS

14

what is the factor that changes with increasing age

renal clearance, even in the presence of normal Creatinine levels

15

which drug MOA treats restless leg syndrome

dopamine agonist (pramipexole)

16

where are the Beta1 receptors that ABEAM beta blockers act on?

cardiomyocytes
JGA cells

(vascular SM has beta2 receptors)

17

what is the term for lip smacking, biting, grimacing, tongue protrusions, and choreoathetoid movements of the had, limbs, and trunk?

tardive dyskinesia

potentially irreversible movement disorder due to prolonged antipsychotic exposure (yrs)

18

what is the term for inner restlessness and inability to sit/stand in one position with antipsychotic meds

akathisia

frequently misdiagnosed worsening psychotic agitation
--you should decrease (not increase) this pt's antipsychotic dosage

19

what involuntary muscle contraction of neck, mouth, tongue, or eye muscles occurs within days of starting an antipsychotic drug?

acute dystonia

especially high potency first gen antipsychotics (Haloperidol)

20

what is chlordiazepoxide drug type

benzodiazepine

21

what's first line for juvenile myoclonic epilepsy and generalized epilepsy

valproic acid, a broad-spectrum anti seizure

22

how do you reverse arsenic/insectaside poisoning

dimercaprol, a chelating agent

pts present with abdominal pain, vomiting, diarrhea, hypotension, GARLIC BREATH,

23

what can you use to reverse acute lead poisoning

CaNa2EDTA

it forms non-ionizing salts and increases urinary lead excretion

24

what do you use to reverse iron overdose/overlaod

deferoxamine

chelating agent that binds circulating iron and facilitates urinary excretion

25

how do you reverse cyanide poisoning

hydroxycobalamin (Vit B12 precursor)

pts present with confusion, CHERRY RED SKIN, vomiting, etc

26

which drug is a selective MAO-B inhibitor

selegiline

27

which drug is as effective as aspirin in preventing cardiovascular events in pts with CAD

clopidogrel

it irreversibly blocks the P2Y12 component of ADP receptors on pltsurface and prevents platelet aggregation

28

do you expect high or low phosphatidylcholine levels in a pt with gallstones

low

it helps dissolve cholesterol

29

what is worrisome about removing an hydatid cyst in surgery

anaphylactic shock

30

what causes Mallory Weiss tears

increased intraluminal gastric pressure, usually from vomiting