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Flashcards in 7/27 Deck (14)
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1

which amino acid is used to make nitric oxide

arginine

2

what is protective for ovarian cancer

decreasing the frequency of trauma that comes with ovulation- including things like OCPs, multiparty, breastfeeding, salpingo-oophorectomy

3

what is the pathogenesis of osteogenesis imperfecta

bone matrix FORMATION (type 1 collagen)

4

which disease has defective bone matrix mineralization

Vitamin D deficiency

5

what side effect can worsen when you add carbidopa to levodopa

behavior (anxiety/agitation)

carbidopa is making more dopamine available in the brain,
but it reduces most of the peripheral side effects of levodopa (N/V)

6

what does positive T cell selection give you

T cells that can recognize self


negative selection eliminates high-affinity interaction with MHC molecules on T cells

7

which receptor works to relax uterus muscles

beta 2 agonist

8

which 2 lipid lowering agent combo gives you the biggest risk for myopathy

fibrates and statin

9

which lipid agent lowers triglycerides

fibrates

10

which drug causes arteriolar dilation, increased renal perfusion, and diuresis and natriuresis in a hypertensive crisis?

fenoldapam

peripheral dopamine-1 agonist

11

how do ACE inhibitors cause nephrotoxicity and acute renal failure

acute rise in serum Cr by blocking angiotensin-mediated efferent vasoconstriction.
this leads to reduction in renal filtration fraction.

ACE inhibitors can therefore cause acute renal failure in pts who are dependent on that efferent arteriole construction to maintain renal perfusion (Renal artery stenosis)

12

what is insulin's signaling pathway

receptor tyrosine kinase signaling to synthesize glycogen, proteins, fatty acids, nucleic acids

Tyrosine kinase/phosphatidylinositol-3-kinase stimulation promotes glycogen synthesis via activating protein phosphatase, an enzyme that dephosphorylates/activates glycogen synthase

13

what's the best indicator of the severity of mitral regurg

presence of an S3

indicates high regurg volume and left ventricular volume overload

14

when do you see Cheyne-Stokes breathing

advanced congestive HF