Adenosine Flashcards Preview

Preg Cat: C > Adenosine > Flashcards

Flashcards in Adenosine Deck (9):
1

Class

  • Endogenous nucleotide
  • Antiarrhythmic

2

Mechanism of action

  • Slow conduction through AV node
  • Interrupt re-entrant pathways
  • Slow impulse formation in SA node
  • Drug of choice for SVT
  • Diagnostic tool for stable wide-complex tach of unknown origin after 2 doses of Lidocain

3

Indications

  • Convert PSVT to sinus rhythm
  • Convert re-entry SVT due to WPW
  • Not effective in converting A-fib/A-flutter or VT

4

Contraindications

  • 2nd or 3rd deg AV block 
  • Sick sinus syndrome 
  • A-fib, A-flutter, VT
  • Hypersensitivity
  • Poison or drug induced tachycardia

5

Side effects

  • H/A
  • Dizziness
  • SOB & bronchospasm
  • Dysrhythmias & palpitations
  • Hypotension
  • Facial flushingDiaphoresis
  • Nausea
  • Metallic taste
  • CP & Px in head or neck
  • Paresthesia

6

Drug interactions

  • Methylxanthines antagonize (theophylline-like drugs)
  • Dipyridamole potentiates  (Persantine)
  • Carbamazepine may potentiate AV node blocking effects (Tegretol)
  • May cause bronchoconstriction in asthmatic pt

7

Dosage and administration

  • Adult:
    • 6-mg rapid IV push over 1-3 seconds
      • 20-mL flush
    • If no response after 1-2 min, give 2nd dose of 12 mg  
    • If no response give 12 mg again.  Max total dose, 30 mg
  • Pediatric:
    • Initial dose 0.1-0.2mg/kg rapid IV push 
    • Max single dose, 12 mg

8

Duration of action

  • Onset:      Seconds
  • Peak effect:  Seconds
  • Duration:      12 seconds.

9

Special considerations

  • Pregnancy Cat C
  • Short half-life limits side effects
  • May cause bronchoconstriction in asthma pt
  • Evaluate elderly for signs of dehydration requiring fluid replacement prior to administration