Promethazine Flashcards

1
Q

Promethazine

Class

A
  • Antihistamine
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2
Q

Promethazine

MOA

A
  • H1 receptor antagonist
  • Blocks action of histamine
  • Sedative qualities
  • Antiemetic qualities
  • Antimotion qualities
  • Anticholinergic qualities
  • Potentiates effects of narcotics to induce analgesia
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3
Q

Promethazine

Indications

A
  • Nausea
  • Vomiting
  • Motion sickness
  • Sedation for pt’s in labor
  • Potentiation of analgesic effects of narcotics
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4
Q

Promethazine

Contraindications

A
  • Hypersensitivity
  • Coma
  • CNS depressed pt’s from:
    • alcohol
    • barbiturates
    • narcotcs
    • Reye’s syndrome
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5
Q

Promethazine

Adverse reactions

A
  • Sedation
  • Dizziness
  • Impairment of mental & physical ability
  • Arrhythmias
  • N/V
  • Hyperexcitability
  • Hallucinations
  • Convulsions
  • Sudden death when used in children
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6
Q

Promethazine

Drug Interactions

A
  • Additive with other CNS depressants
  • Increased extrapyramidal effects with MAOI’s
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7
Q

Promethazine

Dosage

A
  • Adult:
    • 12.5 - 25 mg IV, deep IM, PO, rectally
  • Ped (greater than 2 yo):
    • 0.25 - 0.5 mg/kg IM
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8
Q

Promethazine

Duration of action

A
  • Onset IV: Immediate
  • Peak: 30-60 min
  • Duration: 4-6 hrs
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9
Q

Promethazine

Special Considerations

A
  • Preg Cat: C
  • Use caution in pt’s that have:
    • asthma
    • peptic ulcer disease
    • bone marrow suppression
  • Do not use in children with vomiting of unknown etiology
  • Avoid-intra-arterial injection
  • IM is preferred route
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