Promethazine Flashcards Preview

Preg Cat: C > Promethazine > Flashcards

Flashcards in Promethazine Deck (9):
1

Class

  • Antihistamine

2

MOA

  • H1 receptor antagonist
  • Blocks action of histamine
  • Sedative qualities
  • Antiemetic qualities
  • Antimotion qualities
  • Anticholinergic qualities
  • Potentiates effects of narcotics to induce analgesia

3

Indications

  • Nausea
  • Vomiting
  • Motion sickness
  • Sedation for pt's in labor
  • Potentiation of  analgesic effects of narcotics

4

Contraindications

  • Hypersensitivity
  • Coma
  • CNS depressed pt's from:
    • alcohol
    • barbiturates
    • narcotcs
    • Reye's syndrome

5

Adverse reactions

  • Sedation
  • Dizziness
  • Impairment of mental & physical ability
  • Arrhythmias
  • N/V
  • Hyperexcitability
  • Hallucinations
  • Convulsions
  • Sudden death when used in children

6

Drug Interactions

  • Additive with other CNS depressants
  • Increased extrapyramidal effects with MAOI's

7

Dosage

  • Adult:
    • 12.5 - 25 mg IV, deep IM, PO, rectally

 

  • Ped (greater than 2 yo):
    • 0.25 - 0.5 mg/kg IM 

8

Duration of action

  • Onset IV:  Immediate
  • Peak: 30-60 min
  • Duration:  4-6 hrs

9

Special Considerations

  • Preg Cat: C
  • Use caution in pt's that have:
    • asthma
    • peptic ulcer disease
    • bone marrow suppression
  • Do not use in children with vomiting of unknown etiology
  • Avoid-intra-arterial injection
  • IM is preferred route