Dopamine Flashcards Preview

Preg Cat: C > Dopamine > Flashcards

Flashcards in Dopamine Deck (9):
1

Class

  • Sympathomimetic
  • Inotropic agent

2

MOA

  • Immediate metabolic precursor to norepi
  • Increases systemic vascular resistance
  • Dilates renal and splanchnic vasculature
  • Increases myocardial contractility and stroke volume

3

Indications

  • Cardiogenic shock
  • Septic shock
  • Spinal shock
  • Hypotension with low cardiac output states

4

Contraindications

  • VF

  • Tachyarrhythmias

  • Hypovolemic shock

  • Phechromocytoma (tumor of adrenal glands)

5

Adverse reactions

  • Cardiac arrhythmias
  • HTN
  • Increased myocardial O2 demand
  • Extravasation may cause tissue necrosis

6

Drug interactions

  • Incompatible in alkaline solutions
  • MAOIs enhance effects
  • Bretylium may potentiate effect (antiarrythmic)
  • Beta-blockers may antagonize effects
  • When administered with phenytoin (sz) may cause:
    • hypotension
    • bradycardia
    • sz

7

Dosage

  • Adult & Ped:  2-20 µg/kg/min, titrate for effect
  • Dopaminergic response: (dilates vessels in kidneys; increased urine output):  2-4µg/kg/min

  • Beta-adrenergic response: (positive chronotropic & inotropic):  4-10µg/kg/min

  • Alpha stimulant/vasoconstict:  10-20µg/kg/min
  • Reverse renal effects/override alpha effects:                     > 20 µg/kg/min

 

8

Duration of action

  • Onset:  1-4 min
  • Peak:   5-10 min
  • Duration: effects cease almost immediately after infusion is shut off

9

Special considerations

  • Preg Cat: C
  • Effects are dose dependant
  • Avoid extravasation
  • Always monitor drip rate