Morphine Flashcards Preview

Preg Cat: C > Morphine > Flashcards

Flashcards in Morphine Deck (9):
1

Class

  • Opioid analgesic (Sched II)

2

Mechanism of action

  • Alleviates pain through CNS action
  • Suppresses fear & anxiety center in brain
  • Depresses brain stem respiratory centers
  • Decreases preload and afterload, which decrease myocardial O2 demand
  • Increases peripheral venous capacitance and decreases venous return

3

Indications

  • Severe CHF
  • AMI
  • Pulmonary Edema
  • Analgesia for moderate to severe acute & chronic pain

4

Contraindications

  • Head injury
  • Exacerbatetd COPD
  • Decreased respiratory drive or LOC
  • Hypotension
  • MAOI's within 14 days
  • Undiagnosed ABD pain
  • Suspected hypovolemia

5

Adverse reactions

  • Respiratory depression, bronchospasm
  • Hypotension, Syncope
  • Decreased LOC
  • N/V
  • Bradycardia
  • Tachycardia
  • Euphoria
  • Facial flushing
  • Drymouth

6

Drug interactions

  • Potentiates sedative effect of phenothiazine
  • CNS depressants may potentiate effects of morphine
  • MAOI's may cause paradoxical excitation

7

Dosage and administration

  • Adult:
    • Initial dose: 2-4 mg IV over 1-5 min q 5-30 min
    • Repeat dose: 2-8 mg at 5-15 min intervals
  • Peds:
    • 0.1-0.2 mg/kg per dose, IV, IM, SC
    • Max dose of 5 mg

8

Duration of action

  • Onset: Immediate
  • Peak Effect: 20 min
  • Duration: 2-7 hrs

9

Special considerations

  • Pregnancy: Cat C
  • Rapidly crosses the placenta
  • Safety in neonate not established
  • Use with caution in geriatrics, COPD, & Asthmatic pts
  • Vagotonic effect in pt with acute inferior MI
    • (bradycardia, heart block)
  • Narcan should be available