Flashcards in Adenovirus Deck (33):
What type of infections can Adv cause?
respiratory, eye, and GI tract infections
How long can the virus be shed?
where can the virus be shed from?
primarily lymphoid tissues such as tonsils, adenoids, and Peyer's patches
Adv infection of epithelial cells can lead to what?
significant necrosis and inflammation
What are characteristics of Adv?
double-stranded linear DNA genome packaged in an icosahedral capsid w/out an envelope
What are Adv's exceptionally stable against?
detergents and many other chemicals and physical agents allow them to survive for prolonged periods outside the body. resistant to low pH environment of GI tract
What are the 100 serotypes defined by?
capsid's penton protein
What is a penton protein?
a spike-like protein found at each of the icosahedron's corner.
What is the function of a penton?
attachement proteins of the virus and responsible for toxic effect on cells.
How can one acquire immunity against a particular serotype?
production of penton-specific antibodies
What do Adv hexon proteins do?
produce complement fixing antibodies that don't provide immunity but are useful in IDing an Adv infection
What diseases are caused by Adv?
pharyngitis, pharyngoconjunctival fever, croup, pneumonia, ARD, conjunctivitis, epidemic keratoconjunctivitis, acute gastroenteritis, obesity?!
What happens in the acute phase of infection?
initial replication at site of infection causes cell necrosis and inflammation
What happens after the acute phase?
Adv may persist w/out causing disease in tonsils, adenoids, or Peyer's patches and be shed for 6-18 months
Who is at greatest risk for respiratory infections and acute febrile disease
young children, less than 3 year olds; military recruits
How can one get eye infections from Adv?
contaminated swimming pools or contaminated ophthalmic medicines
What is a classic presentation of Adv infection?
pharyngoconjunctival fever, a combination of pharyngitis and ocular infection
What serotypes cause GI infections? in whom?
40 and 41, in young kids
What is the main organism that causes GI infections?
What are serotypes 36 and 37 linked to?
What are symptoms for a respiratory Adv infection?
cough, fever, sore throat, runny nose, watery eyes
What are the symptoms for an ocular Adv infection?
sand in the eye, runny nose, fever, sore throat
What are the symptoms for a GI Adv infection?
diarrhea, vomiting, fever, nausea, blood in urine
How is Adv transmitted?
inhalation of water droplets; by fecal-oral route, or by direct inoculation
What serotypes are endemic and cause infections in very young kids?
1, 2, 3, 5
When do most endemic infections occur?
in late winter or early spring
What serotype is ARD assoicated w/
4 and 7
How does one Dx Adv?
culture samples (throat or conjunctival swabs, mouth washings, urine, or feces) and clinical presentation
How can one confirm serotypes of Adv?
- penton-specific immunofluroescent antibodies
- hemagglutination inhibition assays
- antibodies to Adv hexon proteins in complement fixation assays confirm infection but not specific serotypes
What does confirmation of an Adv infection entail of?
a comparison of acute and convalescent sera, look for a 4- fold rise in convalescent titer
What is the treatment for Adv?
none, try to treat the symptoms
Is there a vaccine?
attenuated, live vaccine given to military personnel