Rhinovirus Flashcards Preview

Pulmonary Micro > Rhinovirus > Flashcards

Flashcards in Rhinovirus Deck (13):
1

What sense RNA is Rhinovirus and is it enveloped?

+RNA, non-enveloped

2

What consequence does not having an envelope have on Rhinovirus?

It cannot survive outside the nasopharynx because of increased temp and lower ph in stomach; they can live on surfaces

3

What is the mechanism of infection for Rhinovirus?

RV serotypes based on receptor specificity for ICAM-1, LDL-R and Sialoprotein Receptors

4

How does Rhinovirus replicate?

By using the IRES mechanism; viral protease cleaves cap to disable host

5

What disease does RV cause?

MCC Common Cold

6

Briefly describe the infection process of RV.

Infection in nose > 12-72 hr incubation (viral proteases promoting viral synthesis in nasal cells during this) > viral inflammation > local inflammatory response responsible for symptoms

7

What are the symptoms of Cold?

Nasal discharge, sneezing, obstruction, throat infection

8

What is diagnosis based on?

Symptoms

9

What symptoms would make you consider an alternate diagnosis?

Fever/Systemic --> alternate bug
Erythema/edema/exudate --> other bug
Conjuctivits/nasal polyps --> adenovirus

10

What is the treatment of rhinovirus?

Self limiting; treat symptoms; NO vaccine b/c over 100 serotypes

11

When is this virus most likely to happen?

In the fall and spring; independent of cold exposure

12

How is it transmitted?

Exposure to infected respiratory secretions via inhalation

13

How can you distinguish between other viruses that cause cold and Rhinoviruses?

RV's DO NOT PRESENT with nasopharyngitis or serious lung infection