Tularemia -- Francisella Tularensis Flashcards Preview

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Flashcards in Tularemia -- Francisella Tularensis Deck (17):
1

What type of bacteria is Francisella Tularensis?

aerobic, gram-negative, non motile and non sporing

2

What is the main reservoir for Francisella?

Rabbits

3

What is the incubation period fro Francisella?

3-5 days

4

What symptoms do people who develop pneumonic tularemia experience?

chest pain, bloody sputum, difficulty breathing

5

T or F. Francisella is considered a Catergory A biodefense agent.

True

6

What are the virulence factors for Francisella?

LPS - decreases immunostimulatory property
Bacterial capsule
Transposon mutagenesis

7

What is the most common form of the disease caused by Francisella?

Ulceroglandular tularemia

8

What are the symptoms for ulceroglandular tularemia?

- skin ulcer
- swollen and painful lymph glands
- fever
- chills
- headache
- exhaustion

9

What are the symptoms for glandular tularemia?

same as ulcerolandular except no skin ulcers

10

What are the symptoms for oculoglandular tularemia?

eye pain, eye redness, eye swelling and discharge, an ulcer on the inside of the eyelid

11

What are the symptoms for oropharyngeal tularemia?

fever, sore throat, vomiting, diarrhea

12

What are the symptoms for pneumonic tularemia?

cough, chest pain, difficulty breathing,

13

What are the symptoms for typhoidal tularemia?

high fever, extreme exhaustion, vomiting and diarrhea, enlarged spleen/liver, pneumonia

14

What are the ways that tularemia can be transmitted?

1. insect bites- ticks and deerflies
2. exposure to sick or dead animals
3. Airborne bacteria - cause pneuominc tularemia
4. contaminated food or water - causes digestive problems (oropharyngeal tularemia)

15

How does one Dx tularemia?

blood culture, blood test, CXR, PCR from ulcer sample

16

What antibiotics can be used to treat tularemia?

streptomycin, gentamicin, tetracycline

* tetracycline and chloramphenicol have a high relapse rate and aren't a first line- treatment

17

What does one find on a CXR for tularemia?

patchy infiltrates