B. Anthrax Flashcards Preview

Pulmonary Micro > B. Anthrax > Flashcards

Flashcards in B. Anthrax Deck (15):
1

Gram stain?

Positive. Spore-forming rod.

2

Aerobic or anaerobic?

aerobe

3

What is the infectious form?

Spore (lasts 100 yrs in soil). 1-5 um in size will reach lungs.

4

What's special about the capsule?

Made of poly-d-glutamic acid=anti-phagocytic non-antigenic

5

What's different about its A+B model?

There are two A's

6

A1?

Edema Factor: calmod activated AC that increases cAMP resulting in mediastinal edema.

7

A2?

Lethal Factor: metalloprotease cleaves MAPK resulting in cell death.

8

Animal reservoir?

Cows

9

Cutaneous Anthrax disease?

Eschar and swelling

10

Inhalation Anthrax?

Phase 1: flu-like symptoms WITHOUT rhinorrhea
Phase 2: hemorrhagic mediastinitis w/ pleural effusions

11

How is anthrax different from the flu?

No rhinorrhea but will have SOB, nausea, vomit (unlike flu).

12

How is anthrax different from pneumonia?

Mediastinal widening present b/c of infection to hilar/mediastinal lymph nodes

13

Diagnosis?

Gram stain, IF Ab stain CSF, blood smears for G+ box cars. No spores will be seen.

14

Treatment?

40 days ciprofloxacin/doxy IV prophylaxis + ampicillin. Vaccine.

15

Incubation time?

Up to 6 weeks.