Flashcards in B. Anthrax Deck (15):
Positive. Spore-forming rod.
Aerobic or anaerobic?
What is the infectious form?
Spore (lasts 100 yrs in soil). 1-5 um in size will reach lungs.
What's special about the capsule?
Made of poly-d-glutamic acid=anti-phagocytic non-antigenic
What's different about its A+B model?
There are two A's
Edema Factor: calmod activated AC that increases cAMP resulting in mediastinal edema.
Lethal Factor: metalloprotease cleaves MAPK resulting in cell death.
Cutaneous Anthrax disease?
Eschar and swelling
Phase 1: flu-like symptoms WITHOUT rhinorrhea
Phase 2: hemorrhagic mediastinitis w/ pleural effusions
How is anthrax different from the flu?
No rhinorrhea but will have SOB, nausea, vomit (unlike flu).
How is anthrax different from pneumonia?
Mediastinal widening present b/c of infection to hilar/mediastinal lymph nodes
Gram stain, IF Ab stain CSF, blood smears for G+ box cars. No spores will be seen.
40 days ciprofloxacin/doxy IV prophylaxis + ampicillin. Vaccine.