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CV exam 1 wk 1 > Adrenergic > Flashcards

Flashcards in Adrenergic Deck (15):
1

vasodilator drugs

1. hydralazine
2. isosorbide dinitrate

2

hydralazine action

arterial vasodilation
(decrease afterload)

3

isosorbide dinitrate action

venous vasodilation
(decrease preload)

4

Compared to ACE-inhibitors, hydralazine-ISDN equally improved

EF, but ACE-inhibitor had a greater reduction in mortality.

5

The fixed dose of hydralazine-ISDN reduced

mortality in AA receiving beta blocker, ACE-inhibitor and a aldosterone antagonist. (A-HeFT)

6

In blacks, difference are seen that may effect drugs.

1. TGFB mRNA
2. increased endothelin 1
3. decreased role of RAA
4. NO deficiency

7

the combination of hydralazine and isosirbide dinitrate is recommended to reduce morbidity and mortality for

patients self described as african americans with NYHA class 3-4 HFrEF receiving optical therapy with ACE inhibitors and BB
(unless contraindicated)

8

ACE inhibitors drug interactions

1. Lithium
2. NSAIDs
3. Salt Substitutes
4. Loop Diuretics
5. K+ sparing Diuretics

9

ACE inhibitors use caution with

elderly patients

10

enaloprol vs hydralazine mortality

mortality is lower with enaloprol

11

enaloprol reduced

risk of disease and mortality
BUT you get bigger bang for your buck in sicker patients. Doesn't seem to help class 1 very much

12

ACE inhibitors are recommended in patients with

HFrEF and current or prior symptoms (unless contraindicated) to reduce morbidity and mortality

13

ARBS are

angiotensin receptor blockers

14

ACE inhibitors reduce the risk of

secondary HF development

15

ARB side effects

1. well tolerated
2. less angioedema,
3. no cough
4. hyperkalemia
5. uricosuric effects