Flashcards in Adrenergic Deck (15):
1
vasodilator drugs
1. hydralazine
2. isosorbide dinitrate
2
hydralazine action
arterial vasodilation
(decrease afterload)
3
isosorbide dinitrate action
venous vasodilation
(decrease preload)
4
Compared to ACE-inhibitors, hydralazine-ISDN equally improved
EF, but ACE-inhibitor had a greater reduction in mortality.
5
The fixed dose of hydralazine-ISDN reduced
mortality in AA receiving beta blocker, ACE-inhibitor and a aldosterone antagonist. (A-HeFT)
6
In blacks, difference are seen that may effect drugs.
1. TGFB mRNA
2. increased endothelin 1
3. decreased role of RAA
4. NO deficiency
7
the combination of hydralazine and isosirbide dinitrate is recommended to reduce morbidity and mortality for
patients self described as african americans with NYHA class 3-4 HFrEF receiving optical therapy with ACE inhibitors and BB
(unless contraindicated)
8
ACE inhibitors drug interactions
1. Lithium
2. NSAIDs
3. Salt Substitutes
4. Loop Diuretics
5. K+ sparing Diuretics
9
ACE inhibitors use caution with
elderly patients
10
enaloprol vs hydralazine mortality
mortality is lower with enaloprol
11
enaloprol reduced
risk of disease and mortality
BUT you get bigger bang for your buck in sicker patients. Doesn't seem to help class 1 very much
12
ACE inhibitors are recommended in patients with
HFrEF and current or prior symptoms (unless contraindicated) to reduce morbidity and mortality
13
ARBS are
angiotensin receptor blockers
14
ACE inhibitors reduce the risk of
secondary HF development
15