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Flashcards in coupling 3 Deck (16):
1

brugada patients have

significantly shortened Q-T interval, indicative of a shortened ventricular action potential

2

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) can results from

1. dominant mutations in RyR2
2. recessive mutations of CasQ2

3

CPVT patients display

do not display ECG abnormalities at rest, but do display abnormalities upon exercise or infusion of catecholamines.

4

RyR1 mutations can cause

malignant hyperthermia and central core disease in skeletal muscle.

5

in the homozygous condition, mutation of CasQ2 would result in

a dramatic loss of lumenal Ca2+ buffering

6

____ are a standard therapy for CPVT.

b-blockers

7

why areactivation of b-adrenergic receptors pro-arrhythmogenic?

because of increase in SR Ca content and phosphorylation of RyR2

8

Heart failure has been suggested to lead to ____

“hyperphosphorylation” RyR2 and contribute in the increased incidence of arrhythmias in patients with heart failure.

9

b-blockers and other standard therapies are not effective for some____

CPVT patients.

10

Blocking ____ might provide an effective therapy.

aberrant Ca release via RyR2

11

Flecainide is a class ____ that blocks ____

1C anti-arrhythmic

cardiac sodium channels.

12

Tetracaine blocks

RyR2, but at doses too high to be clinically useful.

13

Flecainide causes a

dose-dependent decrease in the open time of single, sheep RyR2 reconsitituted into planar lipid bilayers

14

Flecainide reduces the

frequency of spontaneous Ca release events in ventricular myocytes from Casq2-/- mice.

15

which dz has prolonged QT interval?

both TS and TS2 of timothy syndrome

16

which dz has shortened QT interval?

brugada