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Jonathan's Neuroscience > Ageing > Flashcards

Flashcards in Ageing Deck (18):
1

Are we getting more older people in the population because we are living longer?

Technically no, we are just getting more people to live out their natural life expectancy

2

What are some social engineering type factors that influence life expectancy?

better living condition, clean water, better nutrition, free from disease, medical intervention, vaccination

3

What is cellular senescence?

the phenomenon where cells lose the ability to divide in response to DNA damage

4

What is organismal senescence?

the ageing of whole organisms

5

Why does the body system need to keep a reserve? How does this reserve change as you age?

the reserve is there to respond to challenges. Every system loses reverse capacity with age, but the speed of deterioration can vary across different systems

6

What is the biomarker of frailty?

low-grade, chronic inflammation with abnormality in endocrine and coagulation systems

7

What is the level of cytokines associated with frailty relative to normal level?

2-4 fold higher than normal

8

what's the postulated effect of chronic inflammation in frailty?

catabolic effect on muscle mass and strength + related to anorexia

9

What are some inflammatory cytokines involved in frailty?

CRP, IL6, TNF-a

10

What is sarcopenia?

ageing of muscle

11

T/F We lose more type I fibre than type II

False, we lose more fast twitch type 2 muscles with age

12

What's the function of fast twitch muscle?

fine, precise and rapid movement

13

What's Fried's criteria for frailty?

unintentional weight loss (3 or 4 kg in a year in old people), weakness, exhaustion, slow walking speed, low physical activity.

14

How to you define someone as "frail" using Fried's criteria

the person is frail if he has more than 3 proposed criteria

15

What is co-morbidity?

concurrent presence of more than 2 chronic disease

16

T/F Disability, co-morbidity and frailty are different concepts

True, you can be frail without being having disability or co-morbidity

17

What's the risk of having fragmented health services

lots of doctors treating a single patient leading to increased risk of drug interaction and a lack of coordination between specialists

18

How is medical syndrome different to geriatric syndrome?

We hypodeduct presenting symptoms to identify disease in medical syndrome, but with geriatric syndrome, we start with the syndrome and find out the contributing factors