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Flashcards in Functional Organisation of CNS Deck (77):
1

Where does a somatosensory neuron make its first synapse?

all the way up through the dorsal column and synapse at the medulla

2

What are gracile and cuneate nuclei responsible for?

for somatosensation, gracile nucleus is the location for first synapse from the lower body, whereas cuneate is for the upper body

3

T/F the primary somatosensory neuron decussate at the medulla

False, primary neuron runs ipsilaterally. It's the secondary neuron that crosses over

4

The dorsal column is topographically organised. Neurons from the lower body tend to run more ________ while the upper body neurons, like cervical neurons, run more _________. Therefore, gracile nucleus is _______ to cuneate nucleus

medially (medial for lower body)
laterally (lateral for upper body)

Medial, because it receives lower limb neurons

5

At the point of decussation, the name given to the neurons crossing over is?

internal arcuate fibres

6

At the point of decussation at the middle region of spinal cord, where are the fibres of cuneate nucleus in relation to fibres of gracile nucleus?

Gracile is ventral to cuneate
Gracile secondary neurons run laterally to cuneate secondary neurons

7

Where is the second synapse for somatosensation?

At ventral posterolateral nucelus (VPLN) of the thalamus

8

Where are the neurons from lower reigion in relation to neurons from upper region at the thalamic region?

neurons from lower limb (gracile) are lateral to neurons from upper region (cuneate)

9

What is the name of the tract where the secondary neurons run within?

medial lemniscus

10

after synapsing at the thalamus, the tertiary neurons project to which region of the cortex?

Somatosensory cortex (primary, and some secondary), which is posterior to the central sulcus

11

What is the topographical organisation of the primary somatosensory cortex? What is the significance of that?

Neurons from gracile (lower limb) are located more medially, and neurons from cuneate are located more laterally.

There is a cross over of topographic organisation in the course of tertiary neuron

12

What are the sub-divisions of primary somatosensory cortex? How are they organised in relation to the central sulcus?

Area 1, 2, 3a, 3b

from central sulcus - 3a -> 3b -> 1 -> 2
(makes no sense whatsoever)

13

What is an evidence suggesting that there is a secondary somatosensory cortex?

the representation of body structures are repeated in S2

14

How many body maps are there in total for sensory cortex?

4 in primary, 2 in posterior parietal cortex. 6 in total

15

Are slow adapting and fast adpating neurons segregated ?

Yes, there are islands of slow adapting eurons within each topographical map

16

Which sub-division of S1 receive most input?

3b

17

What gives rise to "cognitive touch"?

the integration of information from the four-subdivisions of S1 at S2

18

Area 1 is more for ________, while area 2 is more for _______

area 1 for texture
area 2 for size/shape

19

what is the function of posterior parietal cortex

it receives and integrates inputs from visual, auditory and somatosensory, and it's involved in planning movement and working out where you are spatially

20

Can you reorganise topographic map?

Yes, in an amputated individual, the unused area will get taken up by the nearby areas of neuron

21

What is an example of normal physiological cortical reorganisation

during lactation, there is increased somatosensory input from breasts

22

Do PNS nerve injuries recover?

Yes, but it's never a complete recovery, because there is a lack of specificity with regrowth. The original function can never be restored

23

What the CNS plasticity respond to? What is the significance?

CNS plasticity responds to the frequency of use, not the pattern of use

If there is peripheral nerve injury, the CNS cannot reorganise to restore the PNS function
"erroneous peripheral nerve regeneration does not produce compensatory central plasticity"

24

Where are the reflex patterns generated?

in the spinal cord

25

During development, the growth of spinal cord is ______ than vertebral column, and it stops at the level of _______ , but beyond that, there are bundles of spinal nerves called _______ which give rise to pairs of spinal nerves for the _______

slower
L1/L2
caudal equina
lower limbs

26

What colour is white matter on histological sections?

black

27

What colour is fluid on MRI 1) T1 2) T2

On T1, it is dark
On T2, it is bright

28

Why is there more white matter towards to the upper spinal region?

there are more fibres closer to the head, because spinal roots fan out at each level

29

Where in the spinal cord does the nociceptive neurons run?

in the anterolateral column

30

What are proprio-spinal neurons?

neurons that make connection within the spinal cord

31

What are the two types for pain fibres and what information do they provide?

C fibres - slow, burning pain
A delta fibres - fast, shape pain

32

Why are lower motor neurons often called the final common pathway

Because they receive inputs and modulations from both local interneurons and upper motor neurons

33

What is a motor unit

the motor neuron and the muscles fibres that it innervates

34

What is a motor neuron pool

clusters of motor neurons innervating a group of muscles collectively

35

Muscles are formed in pairs of _________ , and all muscles except for __________ have proprioceptive _________ that transduce _________ into nerve impulse

functional units
extra-ocular muscles
muscle spindles
muscle stretch

36

What is the function of gamma motor neurons?

They adjust the length of muscle spindles so spindles are always in the optimal position to detect muscle length

37

Why are the sensory apparatus for muscle spindles also called interfusal fibres?

because the apparatus has its own fibrous sheath

38

T/F muscle spindles start off as normal muscles

True, but sensory neurons come in to differentiate muscles into spindles

39

What is the function of golgi tendon

respond to amount of force placed on the muscles

40

Golgi tendons are described to be in ______ with muscle fibres, while muscle spindles are in ______ with muscle fibres

series
parallel

41

Why is "knee jerk" a monosynaptic reflex?

there is only one central synapse - sensory neuron picks up the stretch signal and directly feeds it back to the motor neuron for the same muscle

42

What is the function of reflex system?

reflex maintains joint position and posture

43

The sensory neuron excites the motor neuron from the same muscle, but what else does it need to do?

synapse on an inhibitory interneuron to inhibit/relax the antagonist muscle

44

Describe the golgi tendon feedback circuit

golgi tendon regulates force

too much force -> need to drop the load
sensory neuron synapse to two separate interneurons - inhibitory to primary muscle (relax primary)
excitatory to antagonist muscle (contraction)

45

Is golgi feedback circuit monosynaptic?

No, it synapses onto an interneuron first

46

When we step on something sharp, what happens to
1) ipsilateral flexor?
2) ipsilateral extensor?
3) contralateral flexor?
4) contralateral extensor?

1) contracts
2) relaxes
3) relaxes
4) contracts

Ipsilateral muscle groups do the opposite of contralateral ones

47

Why are priospinal neurons short in the lateral region?

Lateral region is more for distal structures like digits. They are more fine movements rather than posture control, so the local interneuron circuits don't need to be long

48

T/F the pattern for reflex tends to change with different starting positions

False, the pattern is the same as long as the stimulus is applied at the same spot. This is because the purpose of reflex is the same even with different starting positions

49

Most interneurons in the spinal cord are _______ , same as the _______ motor neuron

inhibitory
upper

50

What is the clinical presentation of upper motor neuron damage

UMN damage = lifted inhibition on LMN

Increase reflex, tone, and muscle excitability

51

Is Myasthenia Gravis a motor neuron disease

Yes, although there is nothing wrong with the motor neuron

52

What are the two sets of SNS ganglion?

prevertebral and paravertebral ganglion

53

Which part of the ANS nerve is myelinated?

the preganglionic neuron is lightly myelinated

postganglionic neuron is not myelinated

54

What are some non-classical transmitters?

ATP, nitric oxide, neuropeptides

55

What is co-transmission?

multiple transmitters being released with one AP

56

T/F There is one neurotransmitter release site per axon

False, there are multiple release sites

57

Why are some receptors expressed remotely from the synapse? What is the name of this kind of receptor?

Don't know why, but they can be used as exogenous drug targets

They are called extra-junctional receptors

58

Where are the SNS neurons located in the spinal cord?

in the intermediaolateral nucleus

59

What is it important to have ganglions?

the ganglions are essential for integrating and coordinating information before reaching organs

60

What does 1) paravertebral ganglia 2) prevertebral ganglia control?

1) para - constriction of vasculature
2) pre - control smooth muscle

61

T/F SNS ganglia communicates to a single neuron

false, the ganglia works in a divergence and convergence fashion, receiving many signals and sending out many signals

62

What is the function of adrenaline?

it is activated along with the SNS system to double the effect by having circulating adrenaline, activating receptors all throughout the body

63

What are the four PNS ganglion in the cranial region?

Edinger-Westphal nucleus
Salivatory nuclei
Dorsal motor nucleus of vagus
nucleus ambiguus

64

What is the name of the sacral collection of PNS ganglions? In what way are they different to the cranial ganglions?

inferior hypogastric plexus

They have long post-ganglionic neurons
they are mixed with the sympathetic neurons
There is little integration, more like a relay station

65

Do PNS provide circulating factors?

no, the action is more local

66

Do SNS and PNS always work antagonistically?

No, they are not antagonists of each other in functions like
1) salivary secretion
2) tear secretion

67

What are some examples of antagonism of SNS and PNS at cellular level?

control of heart rate and force of contraction
control of airway

68

what are some examples of functional antagonism via different cells?

control of pupil
control of bladder (SNS controls the base, PNS controls the body of the bladder)

69

What are some examples of different but not opposite actions

SNS serous salivary secretion, PNS mucous salivary secretion

SNS for constriction of abdominal vasculature and lipolysis

PNS for tear secretion at the lacrimal gland

70

What is the only correct way of identifying SNS and PNS neurons?

based on the anatomy/location of the preganglionic neurons

71

What is the term describing ANS reflexes involving the brain?

supraspinal reflex

72

What are some sensory inputs to trigger ANS reflex?

chemical signal
distensible organ stretch

73

What are some possible consequences of ANS dysfunction when the spinal cord is severed

bladder, bowel, sexual dysfunction
CV dysregulation
thermal dysregulation

74

What is the main function of nucleus of solitary tract of the medulla?

it's a major integrative centre for ANS function

75

What are the two possible pathways when signal reaches the nucleus of solitary tract?

1) trigger immediate feedback to control local reflexes
2) provide information to higher centres to drive complex response involving other components like emotion/endocrin

76

What is the most important higher centre for autonomic output?

paraventricular nucleus of the hypothalamus

77

ANS provides complex changes around the body. Therefore, what do drugs need to do in order to modulate these complex functions?

Drugs need to target the autonomic centres in the CNS in order to relief the complex connections involving pain, emotion and their relevant physiological changes