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Flashcards in Alcohols Deck (17):
1

Why is there lactic acidosis & hypoglycemia in ethanol metabolism?

Increased metabolism -> inc NADH:NAD+ ration -> diverts pyruvate to lactate & OAA to malate
Aftermath: inhibits gluconeogenesis & stimulates FA synthesis
Consequence: hypoglycemia & hepatic fatty change

2

Responsible for ethanol metabolism at blood levels higher than 100 mg/dL

Microsomal Ethanol Oxidizing System (MEOS)

3

Blood Alcohol Concentration (BAC)

50-100 : Sedation, Subjective high, slower reactions
60-80 : Impairment of driving ability
100-200: Impaired Motor function
>500 : death; respiratory depression

4

Most common complication of chronic alcohol abuse

Liver disease

5

Most common neurologic abnormality in chronic alcoholics

Peripheral neuropathy

6

Wernicke-Korsakoff syndrome

assoc w/ VitB1 thiamine deficiency
Weird ACO - Wernicke
Ataxia, Confusion, Opthalmoplegia
Korsakoff
Irreversible memory loss, confabulation, psychosis

7

What changes in the brain are seen in Wernicke-Korsakoff syndrome?

Hemorrhagic necrosis of the mamillary bodies

8

Cardioprotective alcohol level

10-15 g/day of ethanol (1 bottle of beer) raises HDL levels and may protect against CAD

9

Fetal Alcohol Syndrome

Mental retardation (most common), growth deficiency, microcephaly
Assoc w/ heavy consumption of alcohol during 1st tri

10

Delirium Tremens

H-A-D 48
Hallucinations, Autonomic instability, Delirium
48-72 hrs post discontinuation

11

DOC for Alcohol Withdrawal Syndrome

thiamine
Benzodiazepine (long acting) diazepam
Intermediate acting (lorazepam) - px w/ compromise liver function

12

Drugs to treat Alcohol dependence

Disulfiram- aldehyde dehydrogenase inhibitor
Naltrexone (opioid receptor antagonist)
Acamprosate (NMDA receptor antagonist)

13

Drugs that cause Disulfiram Reaction

Clara took the Pre-Medical Test in the PM

Chlorpropamide
CefoPerazone
CefoMandole
CefoTetan
Procarbazine
Metronidazole

14

Methanol Poisoning

Visual disturbance

15

Treatment for Methanol Poisoning

Ethanol - competitively inhibits oxidation of methanol
Fomepizole - alcohol dehydrogenase inhibitor

16

Ethylene glycol poisoning (antifreeze products)

Severe acidosis & renal damage
due to accumulation of oxalic acid

17

Treatment for Ethylene glycol poisoning

Ethanol
Fomepizole - slows/prevents formation of oxalic acid