Antibiotic agents

Question 0

Bacteriostatic Antibiotics

Answer 0

We’re ECSTaTiC about bacteriostatics

Erythromycin
Clindamycin
Sulfamethoxazole
Trimethoprim
Tetracycline
Chloramphenicol

Question 1

Bactericidal Antibiotics

Answer 1

Very Finely Proficient At Murder

Vancomycin
Fluroquinolones
Penicillins
Aminoglycosides
Metronidazole

Question 2

MOA of Penicillin

Answer 2

binds to PBPs

inhibits transpeptidation in bacterial cell walls

Question 3

Describe the antimicrobial coverage of extended spectrum penicillins

Answer 3

Amoxicillins HELPS kill Enterococci
H. influenzae
E. coli
L. monocytogenes
Proteus
Salmonella

Question 4

Treatment for Psuedombranous colitis

Answer 4

DOC: metronidazole

next line: Vancomycin (oral)

Question 5

Microbial Coverage of 1st Gen Cephalosporins

Answer 5

+PEcKs FIRST

Gram+
Proteus
E. coli
Klebsiella pneumoniae

Question 6

First Gen Cephalosporins

Answer 6

FADer help me FaZ my PHarmacology boards!

CeFADroxil
CeFAZolin
CePHalothin
CePHapirin
CePHradine
CePHalexine

Question 7

Microbial Coverage of 2nd Gen Cephalosporins

Answer 7

HEN PEcKS

H. Influenzae
Enterobacter Aerogenes
Neisseria spp

Proteus Mirabilis
E. coli
K. Pneumoniae
Serratia marcescens

Question 8

2nd Gen Cephalosporins

Answer 8

In a FAMily gathering, you see your FOXy cousin wearing a FUR coat and drinking Tea

CeFAMandole, CeFOXitin, CeFURoxime, CefoTEtan

FAC, LORA the PROfessional AZhOLE is still on the FONe

CeFAClor, LORAcarbef, CefPROzil, CefmetAZOLE, CeFONicid

Question 9

3rd Generation Cephalosporins

Answer 9

FEnge PO ng PERA to fix my TTTTTV
CeFEtamet
CefPOdoxin
CefoPERAzone
CeFIXime
CefTriaxone
CefTazidine
CefoTaxime
CefTizoxime
CefTibuten

Question 10

2nd Gen Ceph that can cross BBB

Answer 10

Cefuroxime

Question 11

Anti- Pseudomonal Cephalosporins

Answer 11

CefTAZidime (3rd)
CeFEPime (4th)
CeFOPerazone (3rd)

Question 12

4th Gen Cephalosporin

Answer 12

Cefipime

Question 13

Mononactam used for resistant beta-lactamases

NO activity against gram positive bacteria or anaerobes

Answer 13

Aztreonam

Question 14

Beta Lactamase Inhibitors

Answer 14

Clavulanic acid
Tazobactam
Sulbactam

Question 15

DOC for MRSA

SE: Red Man syndrome

Answer 15

Vancomycin

Question 16

Drugs of Last Resort

Answer 16

I AM your Last Shot at Victory

Imipenem
Amikacin
Meropenem
Linezolid
Streptogramibs
Vancomycin

Question 17

Protein Synthesis Inhibitors

Answer 17

BUY AT 30, CELLS at 50

30s
Aminoglycosides
Tetracyclines

50s
Chloramphenicol
Erythromycin (Macrolides)
Lincosamides (clindamycin)
Linezolid 
Streptogramins

Question 18

Gray Baby Syndrome
- ashen gray skin
Aplastic anemia (idiosyncratic)

Answer 18

Chloramphenicol

Question 19

MOA: block attachment of T-RNA to acceptor site

SE: tooth enamel dysplasia
photosensitivity

NO to milk!

Answer 19

Tetracycline

Question 20

Only macrolide that is not a CYP450 inhibitor

Answer 20

Azithromycin

Question 21

Causes Pseudomembranous colitis

Answer 21

Clindamycin

Question 22

Clindamycin vs Metronidazole

Answer 22

both for anaerobic infections

clindamycin - above the diaphragm
metronidazole - below the diaphragm

Question 23

Causes arthralgia-myalgia syndrome

Answer 23

Quinopristin-Dalfopristin

streptogramin

Question 24

Postantibiotic effect

Answer 24

Aminoglycosides & flouroquinolone

Question 25

Aminoglycoside w/ Narrowest therapeutic window

Answer 25

Amikacin

Question 26

MOA: bind to 30s ribosomal unit interferes with synthesis of protein synthesis Block formation of initiation complex Cause misreading of code on the mRNA template Inhibit translocation Require O2 transport

Answer 26

Aminoglycosides

Question 27

Aminoglycoside resistance

Answer 27

Plasmid mediated inactivation Amikacin - resistant to many enzyme

Question 28

Aminoglycosides

Answer 28

``` Mean GNATS canNOT kill anaerobes Gentamicin Neomycin Amikacin Tobramycin Streptomycin ``` Are nephrotoxic, ototoxic, teratogens

Question 29

Most vestibulotoxic & nephrotoxic aminoglycosides

Answer 29

Tobramycin | Gentamicin

Question 30

Aminoglycoside used in hepatic encephalopathy | SE: neuromuscular blockade

Answer 30

Neomycin

Question 31

Most ototoxic aminoglycoside

Answer 31

Amikacin, kanamycin

Question 32

MOA: competitive inhibitor of dihydropteroate synthase Resembles PABA

Answer 32

Sulfonamide

Question 33

DOC: P. Jiroveci

Answer 33

Co-trimazole

Question 34

MOA of fluoroquinolones

Answer 34

Inhibits 1) topoisomerase II (DNA gyrase) in gram (-) 2) topoisomerase IV in gram (+)

Question 35

DOC atypical pneumonia

Answer 35

Macrolides

Question 36

SE: tendinitis & tendon rupture

Answer 36

Flouroquinolomes

Question 37

MOA: reactive reduction by ferredoxin forming free radicals that disrup electron transport chain

Answer 37

Metronidazole