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Flashcards in Antibiotic agents Deck (38):
0

Bactericidal Antibiotics

Very Finely Proficient At Murder

Vancomycin
Fluroquinolones
Penicillins
Aminoglycosides
Metronidazole

1

Bacteriostatic Antibiotics

We're ECSTaTiC about bacteriostatics

Erythromycin
Clindamycin
Sulfamethoxazole
Trimethoprim
Tetracycline
Chloramphenicol

2

MOA of Penicillin

binds to PBPs
inhibits transpeptidation in bacterial cell walls

3

Describe the antimicrobial coverage of extended spectrum penicillins

Amoxicillins HELPS kill Enterococci
H. influenzae
E. coli
L. monocytogenes
Proteus
Salmonella

4

Treatment for Psuedombranous colitis

DOC: metronidazole
next line: Vancomycin (oral)

5

Microbial Coverage of 1st Gen Cephalosporins

+PEcKs FIRST

Gram+
Proteus
E. coli
Klebsiella pneumoniae

6

First Gen Cephalosporins

FADer help me FaZ my PHarmacology boards!

CeFADroxil
CeFAZolin
CePHalothin
CePHapirin
CePHradine
CePHalexine

7

Microbial Coverage of 2nd Gen Cephalosporins

HEN PEcKS

H. Influenzae
Enterobacter Aerogenes
Neisseria spp

Proteus Mirabilis
E. coli
K. Pneumoniae
Serratia marcescens

8

2nd Gen Cephalosporins

In a FAMily gathering, you see your FOXy cousin wearing a FUR coat and drinking Tea

CeFAMandole, CeFOXitin, CeFURoxime, CefoTEtan

FAC, LORA the PROfessional AZhOLE is still on the FONe


CeFAClor, LORAcarbef, CefPROzil, CefmetAZOLE, CeFONicid

9

3rd Generation Cephalosporins

FEnge PO ng PERA to fix my TTTTTV
CeFEtamet
CefPOdoxin
CefoPERAzone
CeFIXime
CefTriaxone
CefTazidine
CefoTaxime
CefTizoxime
CefTibuten

10

2nd Gen Ceph that can cross BBB

Cefuroxime

11

Anti- Pseudomonal Cephalosporins

CefTAZidime (3rd)
CeFEPime (4th)
CeFOPerazone (3rd)

12

4th Gen Cephalosporin

Cefipime

13

Mononactam used for resistant beta-lactamases
NO activity against gram positive bacteria or anaerobes

Aztreonam

14

Beta Lactamase Inhibitors

Clavulanic acid
Tazobactam
Sulbactam

15

DOC for MRSA
SE: Red Man syndrome

Vancomycin

16

Drugs of Last Resort

I AM your Last Shot at Victory

Imipenem
Amikacin
Meropenem
Linezolid
Streptogramibs
Vancomycin

17

Protein Synthesis Inhibitors

BUY AT 30, CELLS at 50

30s
Aminoglycosides
Tetracyclines

50s
Chloramphenicol
Erythromycin (Macrolides)
Lincosamides (clindamycin)
Linezolid
Streptogramins

18

Gray Baby Syndrome
- ashen gray skin
Aplastic anemia (idiosyncratic)

Chloramphenicol

19

MOA: block attachment of T-RNA to acceptor site

SE: tooth enamel dysplasia
photosensitivity

NO to milk!

Tetracycline

20

Only macrolide that is not a CYP450 inhibitor

Azithromycin

21

Causes Pseudomembranous colitis

Clindamycin

22

Clindamycin vs Metronidazole

both for anaerobic infections

clindamycin - above the diaphragm
metronidazole - below the diaphragm

23

Causes arthralgia-myalgia syndrome

Quinopristin-Dalfopristin
(streptogramin)

24

Postantibiotic effect

Aminoglycosides & flouroquinolone

25

Aminoglycoside w/ Narrowest therapeutic window

Amikacin

26

MOA: bind to 30s ribosomal unit interferes with synthesis of protein synthesis
Block formation of initiation complex
Cause misreading of code on the mRNA template
Inhibit translocation
Require O2 transport

Aminoglycosides

27

Aminoglycoside resistance

Plasmid mediated inactivation

Amikacin - resistant to many enzyme

28

Aminoglycosides

Mean GNATS canNOT kill anaerobes
Gentamicin
Neomycin
Amikacin
Tobramycin
Streptomycin

Are nephrotoxic, ototoxic, teratogens

29

Most vestibulotoxic & nephrotoxic aminoglycosides

Tobramycin
Gentamicin

30

Aminoglycoside used in hepatic encephalopathy
SE: neuromuscular blockade

Neomycin

31

Most ototoxic aminoglycoside

Amikacin, kanamycin

32

MOA: competitive inhibitor of dihydropteroate synthase

Resembles PABA

Sulfonamide

33

DOC: P. Jiroveci

Co-trimazole

34

MOA of fluoroquinolones

Inhibits
1) topoisomerase II (DNA gyrase) in gram (-)
2) topoisomerase IV in gram (+)

35

DOC atypical pneumonia

Macrolides

36

SE: tendinitis & tendon rupture

Flouroquinolomes

37

MOA: reactive reduction by ferredoxin forming free radicals that disrup electron transport chain

Metronidazole