Sedative-Hypnotic Drugs Flashcards Preview

Pharmacology 1 > Sedative-Hypnotic Drugs > Flashcards

Flashcards in Sedative-Hypnotic Drugs Deck (17):
1

Major Inhibitory Neurotransmitters

GABA (CNS)
Glycine (Spinal cord)

2

Major Excitatory Neurotransmitters

Glumate
Aspartate

3

Glycine antagonist

Strycline

4

GABA receptor effects

FREnzodiazepines: FREquency
BarbiDURATes: DURAtion

5

Benzodiazepine Toxicity

Anterograde Amnesia

6

CI in Intermittent Porphyria

Barbiturates

7

Benzodiazepines

Midazolam (short acting)
Lorazepam (Intermediate acting)
Diazepam (Long-acting)

8

What abnormal sleep pattern results from use of benzodiazepines?

decrease REM sleep

9

DOC for Status epilecticus

Diazepam

10

Benzodiazepine w/ the longest halflife

Chlordiazepoxide

11

Date rape drugs

Alcohol (most common)
Flunitrazepam (rohypnol)
Gamma-hydroxybutyrate

12

Antidote for Benzodiazepine overdose

Flumazenil - BZ antagonist

13

Barbiturates

Thiopental (ultrashort acting)
Pentobarbital (short-intermediate acting)
Phentobarbital (long-acting)

14

DOC for children w/ insomia, seizure disorders, status epilepticus
Gilberts syndrome

Phenobarbital

15

Enzyme deficient in Acute Intermittent porphyria

HMD synthase

16

DOC for patients w/ Insomnia ONLY

Zolpidem -selective binding to GABA A receptors
Lack anti-convulsant, anti-anxiety, and muscle relaxant

17

Use in General Anxiety Disorder
MOA- Partial agonist at 5HT1A receptor and possibly D2 receptors

Buspirone