General Anesthetics Flashcards Preview

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Flashcards in General Anesthetics Deck (12):
1

Highest MAC and lowest partition coefficient among inhaled anesthetics. Lowest Potency. Rapid onset and recovery

Nitrous oxide

2

Lowest MAC and highest partition coefficient among inhaled anesthetics. Highest Potency. Slow onset and recovery

Methoxyflurane

3

Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: megaloblastic anemia; euphoria (laughing gas)

Nitrous oxide

4

Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Bronchospasms (pulmonary irritant)
Pungent smelling

Desflurane

5

Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Renal insufficiency (compound A)
Sweet smelling

Sevoflurane

6

Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Coronary steal syndrome

Isoflurane

7

Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Spike-and wave activity, muscle twitching, breath-holding

Enflurane

8

Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Post operative Hepatitis
Malignant Hyperthermia

Halothane
Tx. for Malignant hyperthermia: Dantrolene

9

Class: General Anesthetic (IV)
MOA: Blocks excitation by glutamate at NMDA receptors
Uses: Dissociative anesthesia (analgesia, amnesia, & catatonia w/ retained consciousness)
SE: Emergence Delirium

Ketamine

10

Class: General Anesthetic (IV)
MOA: Modulates GABAa receptors containing B3 subunits
Use: General anesthesia (px w/ limited cardiac or respiratory reserve)

Etomidate

11

Class: General Anesthetic (IV)
MOA: interact w/ opiod receptors
SE: Respiratory depression
Antidote is ?

Fentanyl
Antidote: Naloxone
Neuroleptanesthesia - fentanyl + droperidol + nitrous oxide

12

Milk anesthesia

Propofol
Potentiates GABA-A receptor; Blocks Na channels