Drugs used in parkinsonism Flashcards Preview

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Flashcards in Drugs used in parkinsonism Deck (13)
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1
Q

Signs & symptoms of parkinson disease

A

TRAP Tremor Rigidity Akinenesia Postural disturbance

2
Q

Drugs that may induce parkinsonism

A

Antipsychotics (Typical) Reserpine MPTP (methylphenyltetrahydropyridine)

3
Q

Class: Antiparkinsonism

MOA: Dopamine precursor. Inhibits peripheral metablosim via dopa decarboxylase

Uses: DOC of Parkinson’s disease

SE: On-off phenomena, Wearing off phenomena

CI: Px w/ Psychosis

A

Levodopa-Carbidopa

4
Q

Parkinsonian Phenomena

  • alternating periods of improved mobility and akinesia, occuring over a few hours to days during treatment
A

On-off phenomena

5
Q

Parkinsonian Phenomena

  • Deterioration of drug effect in between meication doses
  • Due to progressive destruction of nigriostriatal neurons that occurs w/ disease progression
A

Wearing off phenomena

6
Q

Class: Antiparkinsonism drug

MOA: Partial agonist at D2 receptors

SE: Erythromelalgia, pulmonary fibrosis

A

Bromocriptine

7
Q

Class: Antiparkinsonism drug

MOA: Partial agonist at dopamine D3 receptors in brain

SE: Behavioral changes, Compulsive gambling, hypersexuality, over eating

A

Pramipexole

8
Q

Class: Antiparkinsonism drug

Use: Off-periods of parkinson’s disease, alcoholism

A

Apomorphine

Notes: Premedicate with Trimethobenzamide to prevent nausea

9
Q

Class: Antiparkinsonism drug

MOA: Selective inhibitors of monoamine oxidase type B

A

Selegiline

10
Q

Class: Antiparkinsonism drug

MOA: Block L-dopa metabolism by inhibiting COMT

Use: Parkinson’s disease (wearing-off phenomena)

SE: Sleep disturbance, orange urine, hepatotoxicity (Tolcapone only), Neuroleptic malignant syndrome, rhabdomyolysis

A

Entacapone

11
Q

Class: Antiparkinsonism drug

Antiviral

SE: Livedo reticularis

A

Amantadine

12
Q

Drugs that causes Livedo Reticularis

A

A man reads fHM and GQ

Amantadine

Hydroxyurea

Minocycline

Gemcitabine

Quinidine

13
Q
A