Drugs used in parkinsonism Flashcards Preview

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Flashcards in Drugs used in parkinsonism Deck (13):
1

Signs & symptoms of parkinson disease

TRAP Tremor Rigidity Akinenesia Postural disturbance

2

Drugs that may induce parkinsonism

Antipsychotics (Typical) Reserpine MPTP (methylphenyltetrahydropyridine)

3

Class: Antiparkinsonism

MOA: Dopamine precursor. Inhibits peripheral metablosim via dopa decarboxylase

Uses: DOC of Parkinson's disease

SE: On-off phenomena, Wearing off phenomena

CI: Px w/ Psychosis

Levodopa-Carbidopa

4

Parkinsonian Phenomena

- alternating periods of improved mobility and akinesia, occuring over a few hours to days during treatment

On-off phenomena

5

Parkinsonian Phenomena

- Deterioration of drug effect in between meication doses

-Due to progressive destruction of nigriostriatal neurons that occurs w/ disease progression 

Wearing off phenomena

6

Class: Antiparkinsonism drug

MOA: Partial agonist at D2 receptors

SE: Erythromelalgia, pulmonary fibrosis

Bromocriptine

7

Class: Antiparkinsonism drug

MOA: Partial agonist at dopamine D3 receptors in brain

SE: Behavioral changes, Compulsive gambling, hypersexuality, over eating

Pramipexole

8

Class: Antiparkinsonism drug

Use: Off-periods of parkinson's disease, alcoholism

Apomorphine

Notes: Premedicate with Trimethobenzamide to prevent nausea

9

Class: Antiparkinsonism drug

MOA: Selective inhibitors of monoamine oxidase type B

Selegiline

10

Class: Antiparkinsonism drug

MOA: Block L-dopa metabolism by inhibiting COMT

Use: Parkinson's disease (wearing-off phenomena)

SE: Sleep disturbance, orange urine, hepatotoxicity (Tolcapone only), Neuroleptic malignant syndrome, rhabdomyolysis

Entacapone

11

Class: Antiparkinsonism drug

Antiviral

SE: Livedo reticularis

Amantadine

12

Drugs that causes Livedo Reticularis

A man reads fHM and GQ

Amantadine

Hydroxyurea

Minocycline

Gemcitabine

Quinidine

13