Antiseizure Drugs Flashcards Preview

Pharmacology 1 > Antiseizure Drugs > Flashcards

Flashcards in Antiseizure Drugs Deck (18):
1

MOA- blocks voltage gated Na channels
Uses Grand Mal seizures, partial seizures, arrhythmias (Group 1B)
SE: Gingival hyperplasia, Hirsutism, Fetal hydantoin syndrome

Phenytoin

2

Fetal hydantoin syndrome

Upturned nose, mild midfacial hypoplasia, long upper lip w/ thin vermilion border, lower distal digital hypoplasia

3

Class Tricyclic anticonvulsants
Uses: Grand mal seizures, partial seizures,
Trigeminal neuralgia (DOC)

Carbamazepine

4

Class Anticonvulsant (branch-chain fatty acid)
MOA: blocks high frequency firing of neurons modifies amino acid metabolism
Uses: Grand mal seizures,
Bipolar disorders (acute mania) DOC
Juvenile myoclonic epilepsy DOC
SE: Neural tube defects, spina bifida

Valproic Acid

5

Preferred antiseizure drug in children and pregnant women

Phenobarbital

6

Class Anticonvulsant (cyclic ureide)
MOA: Decrease Ca2+ (T-type) in thalamus
Use: DOC absence seizure (petit mal)

Ethosuximide

7

DOC of status epilepticus

Diazepam
Lorazepam
Phenytoin
Phenobarbital

8

Anticonvulsant drug w/c is also used for neuropathic pain (postherpetic neuralgia) DOC

Gabapentin (GABA derivative)

9

Anticonvulsant that causes SJS

Lamotrigine

10

Anticonvulsant w/ the most number of mechanism of action

Topiramate (monosaccharide derivative)

11

DOC of Generalized Tonic-clonic seizures

Valproic acid
Phenytoin
Carbamazepine

12

DOC partial seizures

Carbamazepine
Lamotrigine
Phenytoin

13

DOC for Absence Seizures

Ethosuximide
Valproic acid

14

DOC for Myoclonic and atypical absence syndromes

Valproic acid

15

DOC for Bipolar affective disorders

Valproic acid (1st line of mania)
Carbamazipine
Lamotrigine

16

DOC for Trigeminal neuralgia

Carbamazipine

17

DOC for Neuropathic pain (Post herpetic neuralgia)

Gabapentin

18

DOC for Migraine

Gabapentin