ALL/CLL

Question 1

Diagnosis of CLL

Answer 1

Peripheral blood smear: lymphocytes more then 5G/L
And less then 55% of cells Beeing atypical

Bone marrow aspirated: showing more then 30% lymphocytes

Immuno: CD5, 19, 20, 23, 52

Question 2

Definition of Acute lymphoblastic leukemia ALL

Answer 2

Neoplastic disease which results from a mutation in a single lymphoid progenitor cell at one of several discrete stages of development
Can be either b or t call

Question 3

Laboratory abnormalities in ALL

Answer 3

Anemia 
WBC: usually low but can be high 
Platelets: low 
LDH high 
Uric acid: high

Question 4

Immunophenotyping in ALL

Answer 4

Differentiate between T&b cell
B: CD 10, 19, 22, 79a
T: CD 3, 7

Question 5

Classifications of ALL FAb

Answer 5

L1: small, similar cells
L2: large differentiated cells
L3: large, differentiated with vacuoles (burkitts)

Question 6

Optimal treatment of CLL?

Answer 6

Anti-CD20 rituximab

Cyclophosphamide (fludarabine)

Question 7

Most common in?

Answer 7

Kids

Or plus 50yo more severe!

Question 8

Age most common for ALL and CLL?

Answer 8

ALL: 2-5 yo

CLL plus 50

Question 9

Cryogenic subtypes of precursor B acute lymphoblastic leukemia

Answer 9

T (12;21) (p12,q22) tel/aml1
T(1;19) (q23;p13) pbx/e2a
T(9,22) (q34;q11) ABL/BCR

Question 10

Most common cryogenic abnormality in CLL

Answer 10

Deletion of 13q14

Question 11

Classification of ALL WHO

Answer 11

1. Acute lymphoblastic leukemia (Fab l1/l2)
2. 1. B-lymphoblastic leukemia
3. 2. T-lymphoblastic leukemia
4. Burkitts leukemia (fab 3)
5. Biphenotypic acute leukemia

Question 12

ALL in adults usually due to?

Answer 12

Cryogenic alteration Ph+

Worst prognosis