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micro DNA virus justus Flashcards

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1
Q

transmission of herpes simplex virus 1 &2

A

direct contact
sexual contact
vertical infection (TORCHES)

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2
Q

pathogenesis of HSV1+2

A 
infects fibroblasts and epithelium cells
1. binds to Heparin sulfate 
2. penetrates cell via Nectin1 and HVEM
3. erlasse proteins into cell 
erlasse of proteins by leysis
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3
Q

how does herpes simplex enter cell?

A

via nectin1 and HVEM

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4
Q

how does HSV bind to cells?

A

interaction via Heparin sulfate

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5
Q

Special mechanism how HSV can escape AB?

A

can jump between cells via intracellular bridges

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6
Q

diseases of HSV1

A
  1. herpes labials (Cold sores)
  2. gingivostimatis
  3. keratoconjuctivitis
  4. hepatic whitlow
  5. erythema multiforme
  6. encephalitis
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7
Q

diseases of HSV2

A
  1. genital herpes
  2. neonateal herpes
  3. asepctic meningigits
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8
Q

diagnosis of HSV1+2

A

Tank smear

intranuclear eosinophilic inclusions Cowdry type a

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9
Q

pathogenesis of EBV

A
  1. infects B cells by binding to the CD21 receipts
  2. creates a atypical reactive CD8 T cell called downey cell
    Latency in Bcells
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10
Q

what is infectious mononucleosis?

A

pharyngitis
lmypahdenopathy
splenomegaly

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11
Q

cancer due to EBV?

A
  1. Hopkins Bell lymphoma
  2. Burkitts
  3. Nasopharyngeal carcinoma
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12
Q

diagnosis of EBV

A

Monospot test

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13
Q

where is HHV5 latened in?

A

mononuclear leukocytes (b and t cell)^

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14
Q

transmission of CMV

A
  1. sexual
  2. transplant organs
  3. vertical torches
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15
Q

pathogenesis of cmv

A

infects slaviary glands epithelium

enters cell via integrin receptor

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16
Q

when is CMV reactivated?

A

when immunosuppression

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17
Q

diseases caused by CMV

A
  1. congetial CMV
  2. esophagitis
  3. CMV colitis
  4. mononucleosis
  5. interstinial pneumonitis
  6. CMV retinitis
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18
Q

what are the symptoms caused by congenital CMV infection?

A
  1. deafness
  2. periventricualr calcification (seizures)
  3. thrombocytic purport (blubbery muffin rash)
  4. jaundice
  5. pneumotitis
  6. hydrops fetales
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19
Q

what is the most common casue of deafness in children?

A

CMV kongenital infection

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20
Q

what is the number 1 fetal infection? viral

A

CMV

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21
Q

diagnosis characteristics of CMV

A

intranuclear basophilic owls eye inclusions

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22
Q

which viruses can be diagnostisized by tank smear?

A
  1. HSV1
  2. HSV2
  3. HHV3 (Zoster)
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23
Q

latency of VZV established in?

A

DRGGL

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24
Q

mode of transmission of VZV?

A

respiratory droplets

vertical Torches

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25
pathogenesis of VZV?
1. enters respiratory tract 2. replicates in local LN 3. priamry viremia to liver and spleen 4. secondary viremia to skin = rash
26
diseases of VZV?
1. Chicken pox 2. shingles (herpes zoster) 3. herpes zoster ophtalmicus 4. congenital varicella syndrome
27
what is chicken pox?
caused by VZV 1. asynchronous rash (different aged lessons) 2. fever, rash, pahrangitis 4. pneumonia 5. encephalitis
28
what is shingles?
1. dermatomal rash | 2. Post herpatic neuralgia
29
what ia congenital varcella syndrome?
1. limp hypoplasia 2. cutanoues dermal scarring 3. blindess
30
prevention of VZV?
1. SUBUNIT vaccine for kids and old ppl | 2. passive immunity for AIDS ppl
31
where does HHV6 establishes latency?
CD4 T cells
32
mode of transmission of HHV6
saliva
33
pathogenesis of HHV 6
replicates in salivary glands infects CD4 tcells casues immonesuppresion by diminishing Tcells
34
diseases caused by HHV6
Roseoka infantum
35
what is roseolar infantum?
caused by HHV 6 1. High fever 2. seizures 3. rash sparing the face
36
where does HHV 8 establishes latency?
in B cells
37
transmission of HHV 8?
saliva | sex
38
pathogenies of HHV8?
infects mainly B cells | HHV8 has a gene which activates vascular endothelial growth (VRGF)
39
which gene is in the genome of HHV8?
VEGF
40
what diseases does HHV8 cause?
1. Kapos sarcoma | 2. primary Effusion B cell lymphoma
41
what is kaposi sarcoma?
``` erythematous violet lesions on nose, extremities and mucosa highly associated to AIDS form vessels that's why they are violet can affect gI mostly on hard palate ```
42
ddx between Kaposi and bacillary angiomatosis?
bacterial infection: neutrophils | viral infection: lymphocytes
43
where does Polyomavirus establishes latency?
BK in kindey | JC in Kinder, B cells, monocytes
44
transmission of polyomavirus
respiratory droplets
45
pathogenesis of polyoma virsu
infects tonsils priamry viremia to kinder seocnday viremia becomes latent or reactivated
46
diseases caused by BK virus
nephropathy Hemorragic cystitis all associated with transplant patients!!!!!
47
diseases caused by John Cunningham virus
progressive multifocal leukoencephalopahty PML
48
what is PML?
``` infection of oligodendrocytes demyelination throught CNS leads to: peach, vision and coordination problems paralzysis DEATH associated with AIDS ```
49
HPV characteristics?
circular dsDNA virus naked icosahedral 75 serotypes-- 1-4, 6, 11, 16, 18, 31, 33
50
diseases caused by HPV different serotypes
1-4: cutanées warts 6, 11: condyloma acumilatat 16, 18: CIN.....
51
smallest DNA virsu
Parvovirus b19
52
genetic material in Parvovrisu b19
linear SINGLE strand DNA
53
transmission of Parvovirus b19?
respiratory doplets | vertical torches
54
pathogenesis of Parvocirus b19?
1. binds to P antigen on immature erythroid progenitor cells 2. endocytosed 3. ssDNA transportet to nucleus 4. froms hairpin loop to make dsDNA 5. makes primer for cells DNA polymerase 6. protein production
55
diseases caused by Parvovirus b19
1. erythema infectiousum 2. hydrops fetalis 3. Anaplastik anemia
56
what erythema infectiousum?
slapped cheek fever starts as low grade fever turns into high grade rash face downwards arthritis
57
what does Parvovirus bind to in pathogenies?
p antigen on immature erythropoietic stems cells
58
explain anapestic anemia in Parvovirus infection
since the erythropoietic steam cells are infected, a decreased number of healthy RCB are in the blood. leading to anemia
59
wich serotype of adenovirus is the worst to humans?
14
60
transmission of adenovirus?
fecal oral respiratory direct contact
61
Pathogenese of adenovirus?
icosahedral capsid ahs pentod which act as hemagglutinin causes lysis in permissive cells casues oncogneic or chronic infection of non permissive cells
62
diseases caused by adenovirus?
1. #1 casue for tonsilitis 2. conjunctivitis (pink eye) 3. ARDS, pneumonis, bronchitis 4. acute hemorrhagic cystitis 5. gastroentrites
63
ddx from strep pyrogens and adenovirus?
culture.
64
which serotypes cause ARDS, bronchitis and pneumonia of adenovirus?
4, 7, 21
65
which serotype of adenovirus causes acute hemorrhagic cystitis?
11, 21
66
which serotypes cause gastroenteritis in adenovirus?
40, 41
67
prevention of Adenovirus?
vaxxine: live attenuated against serotypes 4 and 7
68
what is the largest virus?
poxvirus
69
special things about poxvirus envelope?
can make its own.
70
General characteristics of Poxvirus?
1. linear dsDNA 2. enveloped 3. icosahedral 4. replicates in CYTOPLASMA only dan to do it. 5. brings everything it need.
71
transmission of pox virus
small pox by respiratory droplets | molluscum contagion sum virus by direct contact
72
pathogenies of small pox
enters respiratory tract and replicates in lympathics | secondary viremia wil infect skin tissue and creates pocks
73
disease of small pox virus
fist flu like symptoms rash in mouth to everywhere else in 24h all vesicles are same age!
74
DDX from chicken pox and small pox?
in small pox the vesicles are synchronous. same age.
75
pathogenies and disease of Molluscum contagious virus (MCV)
replicates in dermis water warts: seal like lesions (dome shaped, red, umbilicate) in adults associate HIV infection
76
prevention of Poxvirus
live attenuated against small pox made from cowpox strain.
77
place of replication of Hep B virus?
inside and outside the nucleus
78
which family is HBV in?
Hepadnavirus
79
what kind of polymerase does Hep B virus has?
reverse transkitpase
80
transmission of HBV?
blood Sexual vertical (troches)
81
what causes the symptoms of a HBV infection?
its an type 3 HSR | immunecompelx of HbsAG and Anti-Hbs Ab
82
what are the extra hepatic manifestations of HBV infection?
1. polyarteritis nodosa | 2. golmerolar nephritis
83
diseases caused by hepatitis B virus
1. acute hepatitis 2. Chronik hepatis 3. polyartritis nodosa 4. golmerolar diseases
84
antigen levels explaint
1. HBsAgacitve disease 2. HBeAg infectivity 3. Anti-HBc Ab window period 4. Anti-HBe Ab lower infectivity 5. Anti-HBs Ab healthy

Stuff Thats Would Be Cool To Remember (20 decks)

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