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Stuff Thats Would Be Cool To Remember > micro DNA virus justus > Flashcards

micro DNA virus justus Flashcards

1
Q

transmission of herpes simplex virus 1 &2

A

direct contact
sexual contact
vertical infection (TORCHES)

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2
Q

pathogenesis of HSV1+2

A 
infects fibroblasts and epithelium cells
1. binds to Heparin sulfate 
2. penetrates cell via Nectin1 and HVEM
3. erlasse proteins into cell 
erlasse of proteins by leysis
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3
Q

how does herpes simplex enter cell?

A

via nectin1 and HVEM

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4
Q

how does HSV bind to cells?

A

interaction via Heparin sulfate

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5
Q

Special mechanism how HSV can escape AB?

A

can jump between cells via intracellular bridges

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6
Q

diseases of HSV1

A
  1. herpes labials (Cold sores)
  2. gingivostimatis
  3. keratoconjuctivitis
  4. hepatic whitlow
  5. erythema multiforme
  6. encephalitis
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7
Q

diseases of HSV2

A
  1. genital herpes
  2. neonateal herpes
  3. asepctic meningigits
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8
Q

diagnosis of HSV1+2

A

Tank smear

intranuclear eosinophilic inclusions Cowdry type a

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9
Q

pathogenesis of EBV

A
  1. infects B cells by binding to the CD21 receipts
  2. creates a atypical reactive CD8 T cell called downey cell
    Latency in Bcells
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10
Q

what is infectious mononucleosis?

A

pharyngitis
lmypahdenopathy
splenomegaly

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11
Q

cancer due to EBV?

A
  1. Hopkins Bell lymphoma
  2. Burkitts
  3. Nasopharyngeal carcinoma
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12
Q

diagnosis of EBV

A

Monospot test

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13
Q

where is HHV5 latened in?

A

mononuclear leukocytes (b and t cell)^

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14
Q

transmission of CMV

A
  1. sexual
  2. transplant organs
  3. vertical torches
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15
Q

pathogenesis of cmv

A

infects slaviary glands epithelium

enters cell via integrin receptor

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16
Q

when is CMV reactivated?

A

when immunosuppression

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17
Q

diseases caused by CMV

A
  1. congetial CMV
  2. esophagitis
  3. CMV colitis
  4. mononucleosis
  5. interstinial pneumonitis
  6. CMV retinitis
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18
Q

what are the symptoms caused by congenital CMV infection?

A
  1. deafness
  2. periventricualr calcification (seizures)
  3. thrombocytic purport (blubbery muffin rash)
  4. jaundice
  5. pneumotitis
  6. hydrops fetales
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19
Q

what is the most common casue of deafness in children?

A

CMV kongenital infection

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20
Q

what is the number 1 fetal infection? viral

A

CMV

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21
Q

diagnosis characteristics of CMV

A

intranuclear basophilic owls eye inclusions

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22
Q

which viruses can be diagnostisized by tank smear?

A
  1. HSV1
  2. HSV2
  3. HHV3 (Zoster)
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23
Q

latency of VZV established in?

A

DRGGL

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24
Q

mode of transmission of VZV?

A

respiratory droplets

vertical Torches

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25
Q

pathogenesis of VZV?

A
  1. enters respiratory tract
  2. replicates in local LN
  3. priamry viremia to liver and spleen
  4. secondary viremia to skin = rash
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26
Q

diseases of VZV?

A
  1. Chicken pox
  2. shingles (herpes zoster)
  3. herpes zoster ophtalmicus
  4. congenital varicella syndrome
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27
Q

what is chicken pox?

A

caused by VZV

  1. asynchronous rash (different aged lessons)
  2. fever, rash, pahrangitis
  3. pneumonia
  4. encephalitis
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28
Q

what is shingles?

A
  1. dermatomal rash

2. Post herpatic neuralgia

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29
Q

what ia congenital varcella syndrome?

A
  1. limp hypoplasia
  2. cutanoues dermal scarring
  3. blindess
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30
Q

prevention of VZV?

A
  1. SUBUNIT vaccine for kids and old ppl

2. passive immunity for AIDS ppl

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31
Q

where does HHV6 establishes latency?

A

CD4 T cells

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32
Q

mode of transmission of HHV6

A

saliva

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33
Q

pathogenesis of HHV 6

A

replicates in salivary glands
infects CD4 tcells
casues immonesuppresion by diminishing Tcells

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34
Q

diseases caused by HHV6

A

Roseoka infantum

35
Q

what is roseolar infantum?

A

caused by HHV 6

  1. High fever
  2. seizures
  3. rash sparing the face
36
Q

where does HHV 8 establishes latency?

A

in B cells

37
Q

transmission of HHV 8?

A

saliva

sex

38
Q

pathogenies of HHV8?

A

infects mainly B cells

HHV8 has a gene which activates vascular endothelial growth (VRGF)

39
Q

which gene is in the genome of HHV8?

A

VEGF

40
Q

what diseases does HHV8 cause?

A
  1. Kapos sarcoma

2. primary Effusion B cell lymphoma

41
Q

what is kaposi sarcoma?

A 
erythematous violet lesions on nose, extremities and mucosa
highly associated to AIDS
form vessels that's why they are violet 
can affect gI 
mostly on hard palate
42
Q

ddx between Kaposi and bacillary angiomatosis?

A

bacterial infection: neutrophils

viral infection: lymphocytes

43
Q

where does Polyomavirus establishes latency?

A

BK in kindey

JC in Kinder, B cells, monocytes

44
Q

transmission of polyomavirus

A

respiratory droplets

45
Q

pathogenesis of polyoma virsu

A

infects tonsils
priamry viremia to kinder
seocnday viremia becomes latent or reactivated

46
Q

diseases caused by BK virus

A

nephropathy
Hemorragic cystitis
all associated with transplant patients!!!!!

47
Q

diseases caused by John Cunningham virus

A

progressive multifocal leukoencephalopahty PML

48
Q

what is PML?

A 
infection of oligodendrocytes 
demyelination throught CNS
leads to: peach, vision and coordination problems
paralzysis 
DEATH
associated with AIDS
49
Q

HPV characteristics?

A

circular dsDNA virus
naked
icosahedral
75 serotypes– 1-4, 6, 11, 16, 18, 31, 33

50
Q

diseases caused by HPV different serotypes

A

1-4: cutanées warts
6, 11: condyloma acumilatat
16, 18: CIN…..

51
Q

smallest DNA virsu

A

Parvovirus b19

52
Q

genetic material in Parvovrisu b19

A

linear SINGLE strand DNA

53
Q

transmission of Parvovirus b19?

A

respiratory doplets

vertical torches

54
Q

pathogenesis of Parvocirus b19?

A
  1. binds to P antigen on immature erythroid progenitor cells
  2. endocytosed
  3. ssDNA transportet to nucleus
  4. froms hairpin loop to make dsDNA
  5. makes primer for cells DNA polymerase
  6. protein production
55
Q

diseases caused by Parvovirus b19

A
  1. erythema infectiousum
  2. hydrops fetalis
  3. Anaplastik anemia
56
Q

what erythema infectiousum?

A

slapped cheek fever
starts as low grade fever turns into high grade
rash face downwards
arthritis

57
Q

what does Parvovirus bind to in pathogenies?

A

p antigen on immature erythropoietic stems cells

58
Q

explain anapestic anemia in Parvovirus infection

A

since the erythropoietic steam cells are infected, a decreased number of healthy RCB are in the blood. leading to anemia

59
Q

wich serotype of adenovirus is the worst to humans?

A

14

60
Q

transmission of adenovirus?

A

fecal oral
respiratory
direct contact

61
Q

Pathogenese of adenovirus?

A

icosahedral capsid ahs pentod which act as hemagglutinin
causes lysis in permissive cells
casues oncogneic or chronic infection of non permissive cells

62
Q

diseases caused by adenovirus?

A
  1. # 1 casue for tonsilitis
  2. conjunctivitis (pink eye)
  3. ARDS, pneumonis, bronchitis
  4. acute hemorrhagic cystitis
  5. gastroentrites
63
Q

ddx from strep pyrogens and adenovirus?

A

culture.

64
Q

which serotypes cause ARDS, bronchitis and pneumonia of adenovirus?

A

4, 7, 21

65
Q

which serotype of adenovirus causes acute hemorrhagic cystitis?

A

11, 21

66
Q

which serotypes cause gastroenteritis in adenovirus?

A

40, 41

67
Q

prevention of Adenovirus?

A

vaxxine: live attenuated against serotypes 4 and 7

68
Q

what is the largest virus?

A

poxvirus

69
Q

special things about poxvirus envelope?

A

can make its own.

70
Q

General characteristics of Poxvirus?

A
  1. linear dsDNA
  2. enveloped
  3. icosahedral
  4. replicates in CYTOPLASMA only dan to do it.
  5. brings everything it need.
71
Q

transmission of pox virus

A

small pox by respiratory droplets

molluscum contagion sum virus by direct contact

72
Q

pathogenies of small pox

A

enters respiratory tract and replicates in lympathics

secondary viremia wil infect skin tissue and creates pocks

73
Q

disease of small pox virus

A

fist flu like symptoms
rash in mouth to everywhere else in 24h
all vesicles are same age!

74
Q

DDX from chicken pox and small pox?

A

in small pox the vesicles are synchronous. same age.

75
Q

pathogenies and disease of Molluscum contagious virus (MCV)

A

replicates in dermis
water warts: seal like lesions (dome shaped, red, umbilicate)
in adults associate HIV infection

76
Q

prevention of Poxvirus

A

live attenuated against small pox made from cowpox strain.

77
Q

place of replication of Hep B virus?

A

inside and outside the nucleus

78
Q

which family is HBV in?

A

Hepadnavirus

79
Q

what kind of polymerase does Hep B virus has?

A

reverse transkitpase

80
Q

transmission of HBV?

A

blood
Sexual
vertical (troches)

81
Q

what causes the symptoms of a HBV infection?

A

its an type 3 HSR

immunecompelx of HbsAG and Anti-Hbs Ab

82
Q

what are the extra hepatic manifestations of HBV infection?

A
  1. polyarteritis nodosa

2. golmerolar nephritis

83
Q

diseases caused by hepatitis B virus

A
  1. acute hepatitis
  2. Chronik hepatis
  3. polyartritis nodosa
  4. golmerolar diseases
84
Q

antigen levels explaint

A
  1. HBsAgacitve disease
  2. HBeAg infectivity
  3. Anti-HBc Ab window period
  4. Anti-HBe Ab lower infectivity
  5. Anti-HBs Ab healthy

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