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Flashcards in An introduction to Fungi Deck (18):
1

Mycology

The study of fungi

2

Give a brief summary of what a fungus is

A eukaryote which lacks chlorophyll with ergosterol being the main sterol

3

Can fungi form spores?

Yes

4

Give 3 examples of fungus

Mould, yeast and mushrooms

5

Basidomycetes

Sexual spores are basidospores and have a long tube with basdia underneath the mushroom cup
Examples are mushroom and moulds

6

Ascomycetes

Ascospores contained in a sac
Mould and yeast

7

Zygomycetes

Rough walled zygote containing one or more zygospores
Moulds only

8

Dermatophytes

Use keratin as a nutrient source to create ringworm infection eg pityriasis vesicolor - yeast which forms hyphae in skin

9

Give 2 examples of how host factors can contribute to pathogenicity

- Warm, moist area eg skin and mucous membranes
- Antibacterial agents will reduce competition

10

2 Examples of iatrogenic immunosuppression

Chemotherapy and steroids

11

2 Examples of disease processes immunosuppression

AIDs and Leukaemia

12

Candida

Found in GI tract
Get into blood and cause infection eg oral, vaginal, oesophageal and nail
Especially in seriously immunocompromised hosts

13

Aspergillosis

Moulds ubiquitous due to inhalation if canidia and are strongly angiovasive

14

4 Examples of medical mycology

- High res CT/ histopathology
- Fungal antigen/antibody
- PCR for fungal DNA
- Culture from usual sterile sight

15

3 Antifungals

Azoles, echinocandis and polyenes

16

Azoles

Target ergosterol formation

17

Echinocandis

Target wall and are fungicidal

18

Polyenes

Target membrane and are the gold standard which bind ergosterol and puncture membrane