Flashcards in An introduction to Fungi Deck (18)
1
Mycology
The study of fungi
2
Give a brief summary of what a fungus is
A eukaryote which lacks chlorophyll with ergosterol being the main sterol
3
Can fungi form spores?
Yes
4
Give 3 examples of fungus
Mould, yeast and mushrooms
5
Basidomycetes
Sexual spores are basidospores and have a long tube with basdia underneath the mushroom cup
Examples are mushroom and moulds
6
Ascomycetes
Ascospores contained in a sac
Mould and yeast
7
Zygomycetes
Rough walled zygote containing one or more zygospores
Moulds only
8
Dermatophytes
Use keratin as a nutrient source to create ringworm infection eg pityriasis vesicolor - yeast which forms hyphae in skin
9
Give 2 examples of how host factors can contribute to pathogenicity
- Warm, moist area eg skin and mucous membranes
- Antibacterial agents will reduce competition
10
2 Examples of iatrogenic immunosuppression
Chemotherapy and steroids
11
2 Examples of disease processes immunosuppression
AIDs and Leukaemia
12
Candida
Found in GI tract
Get into blood and cause infection eg oral, vaginal, oesophageal and nail
Especially in seriously immunocompromised hosts
13
Aspergillosis
Moulds ubiquitous due to inhalation if canidia and are strongly angiovasive
14
4 Examples of medical mycology
- High res CT/ histopathology
- Fungal antigen/antibody
- PCR for fungal DNA
- Culture from usual sterile sight
15
3 Antifungals
Azoles, echinocandis and polyenes
16
Azoles
Target ergosterol formation
17
Echinocandis
Target wall and are fungicidal
18