Flashcards in Estimating risk of inherited genetic disease Deck (33)
Relative ability of organisms to survive and pass on genes
What does fitness depend on?
Types of alleles eg neutral, deleterious or advantageous
Do deleterious mutations sometimes or rarely decrease fitness?
Do advantageous mutations sometimes or rarely increase fitness
Frequency of alleles affect healthy population
1 gene with 2 alleles what are p and q
p = dominant q = recessive
Gt/ total alleles ( NB double the number as alleles separate)
Do dominant conditions become more common at the expense or recessive alleles?
What are constant generation to generation?
Allele frequency and relative proportion of genotype frequency
p squared = q squared = 2pq=
What can HWE allow?
Calculate risk in genetic counselling
Plan population based carrier screening programmes
When is HWE not always achieved?
Name some characteristics of an ideal population
- Mutation can be ignored and migration is negligible
- Mating is random and there are no selective pressure
- Allele frequency equal in sexes in large population
Do mutations increase or decrease proportion of new alleles?
What else increases the proportion of new alleles?
Migration and intermarriage
Give an example of migration and proportion of alleles
60% of men in NW Scotland have Scandinavian DNA and leads to a hybrid population
What does non random mating do?
- Increase mutant alleles
- Increase affected homozygotes
Close blood relatives
Gradual process where traits become more or less common in a population
Negative natural selection
Reduces reproductive fitness
Decrease prevalence of traits
Gradual reduction of mutant allele
Positive natural selection
Increases reproductive fitness
Increase prevalence of adaptive traits
Give some examples of heterozygote advantage
Cholera/ typhoid with CF
Sickle cell anaemia for malaria
G6PD for malaria
What do large populations do to fluctuations?
Balance them out