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Flashcards in anaesthetics Deck (6):
1

structure of a local anaesthetic

aromatic region + ester/amide bond: amide bonds have longer half lives and are more widely distributed

2

MOA of local anaesthetics

are weak bases, ionised form blocks Na+ channels, act on inner part, block nerve conduction in order of C fibre, A delta, A beta, A alpha

3

what rapidly hydrolyses ester type local anaesthetics?

pseudo-cholinesterase

4

what hydrolyses amide type local anaesthetics?

liver microsomal P450 enzyme

5

Why are adrenaline and felypressin (non catecholamine) used with local anaesthetics?

vasoconstrictors, temporarily limit the spread of the local anaesthetic into systemic circulation

6

ADRs of local anaesthetics?

CNS - dose-dependent: depression, excitation
- restlessness, shivering, tongue numbness/metallic taste
- CNS depression/convulsions (depression of cortical inhibitory pathways)
- respiratory depression
CV: - myocardial depression/conduction block
- vasodilation
- pronounced fall in BP and death