Antidepressants Flashcards Preview

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Flashcards in Antidepressants Deck (25):
1

Tricyclic antidepressants MOA

inhibit NA and 5-HT reuptake

2

Tricyclic antidepressants ADRs

- antihistaminic, antimuscarinic effects
- orthostatic hypotension
- overdose: cardiac dysrhythmias

3

MOA SSRIs

- block reuptake of 5-HT

4

ADRs SSRIs

- insomnia, nausea, dizziness, anxiety
- increased suicide risk, serotonin syndrome (agitation, restlessness, confusion, rapid heart rate, high BP)

5

uses of SSRIs

depression, anxiety, OCD

6

MOA Tetracyclic antidepressants

block presynaptic alpha-2 receptors

7

ADRs tetracyclic antidepressants

- sedation
- blood toxicity (rare)

8

MOA NSRIs

- block reuptake of 5-HT, DA and NA

9

ADRs NSRIs

- hypertension
- hypercholesterolaemia
- nausea, dizziness, insomnia

10

MOA MAOIs

inhibit MAO

11

ADRs non-selective MAOIs

- if high dietary tyramine, tyramine enters terminal via reuptake-1, causing massive release of NA = hypertensive CRISIS

12

ADRs reversible inhibitors of MAO-A

- sleep disturbances, dizziness, nausea
(more selective for 5-HT and NA, no dietary restrictions)

13

MOA SNRIs

primarily block NA uptake

14

ADRs SNRIs

- dry mouth, constipation, tachycardia

15

What level of depression is St John's wort used for?

mild to moderate

16

ADRs of St John's wort

dry mouth, photosensitivity, headaches, palpitations

17

MOA lithium carbonate

substitutes the Na+ ion, affects Na+/K+ pump, reduces transmitter release

18

ADRs lithium carbonate

narrow range of safety (very toxic)
- cardiac dysrhythmias, convulsions, hypothyroidism, diarrhoea

19

lithium carbonate is used for?

bipolar

20

anti seizure drugs are used for?

mania

21

MOA anti seizure drugs

enhance GABA's effects

22

MOA melatonin agonists

agonist at melatonin receptors, antagonist at some 5-HT receptors
- resets sleep-wake cycle

23

ADRs melatonin agonists

liver impairment, dizziness, headache, sleepiness, GI upset

24

MOA vortioxetine

enhance 5-HT availability, inhibit reuptake

25

ADRs vortioxetine

headache, nausea