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Flashcards in Anti-psychotics drugs Deck (14):
1

MOA 1st generation anti-psychotics

D2 receptor antagonists

2

ADRs of 1st generation anti-psychotics

- motor disturbances - fix with antimuscarinics
- increase prolactin release
- inhibit insulin release
- hypothermia
- suppresses vomiting centre
- cross-react with anti-muscarinics, antihistaminic, antiadrenergics: dry mouth, blurred vision, constipation, urinary retention, sedation, orthostatic hypotension, tachycardia, hypersensitivity and allergic reactions

3

clinical considerations 1st generation anti-psychotics

- good for positive symptoms, not for negative
- therapeutic effect in weeks, ADRs immediate

4

MOA 2nd generation clozapine

may have D4 selectivity

5

ADRs clozapine

absence seizures
sedation
neutropenia

6

why clozapine is better than 1st generation

reduced tardive dyskinesia

7

MOA 2nd generation risperidone

serotonin, D2 antagonist

8

ADR 2nd generation risperidone

weight gain

9

why risperidone over 1st generation

lower incidence of extrapyramidal effects and galactorrhea
can be administered parenterally

10

*olanzapine* over 1st generation

- well tolerated, lower incidence of galactorrhoea

11

ADRs olanzapine

weight gain, constipation, drowsiness

12

MOA aripiprazole

partial D2 agonist, agonist at some 5-HT, antagonist at others

13

ADRs aripiprazole

weight gain, drowsiness

14

why aripiprazole over 1st generation

well tolerated, comparable efficacy to haloperidol