neurodegenerative disorders Flashcards Preview

pharmacology > neurodegenerative disorders > Flashcards

Flashcards in neurodegenerative disorders Deck (17):
1

Features of Alzheimer's disease

- increased cerebral Glut levels, decreased cholinergic neurons
- neurofibrillary tangles develop, malformation of cytoplasmic microtubules
- appearance of deposits of cell debris and excessive amounts of beta-amyloid protein

2

Drugs used for Alzheimer's

- AChE inhibitors (may improve in early stages, 6months-2 years)
- NMDA receptor antagonist (for mod-severe Alzheimer's)
- immune therapy

3

ADRs of AChE

GI disturbances common, dose-related

4

MOA of NMDA receptor antagonists

inhibit prolonged activation of receptor

5

ADRs of NMDA receptor antagonists

agitation, drowsiness, dizziness, headache

6

MOA of immune therapy

mop up Beta-amyloid by inhibiting its formation and enhancing its clearance

7

drugs for Parkinson's disease

L-dopa, DDC inhibitors, COMT inhibitors, amantadine, D2 agonists, MAO-B inhibitors

8

How much of the L-dopa dose is converted to DA in the brain?

1%

9

ADRS of L-dopa

nausea, vomiting, anorexia, orthostatic hypotension, cardiac dysrhythmias, writhing involuntary movements

10

MOA of DDC inhibitors?

improve L-dopa CNS delivery by inhibiting peripheral enzyme

11

MOA of COMT inhibitors?

improves L-dopa CNS delivery by inhibiting peripheral enzyme: inhibition of DDC causes compensatory increase in activity of COMT: products compete with L-dopa in crossing the BBB)

12

ADRs of L-dopa + DDCi + COMT-i?

delusions, hallucinations, confusion, insomnia, nightmares

13

MOA of amantadine?

causes release of DA from neurons still working + inhibits DA reuptake

14

Uses of D2 agonists, MAO-B inhibitors and centrally acting antimuscarinics

adjunct to L-dopa therapy, D2 agonists and MAO-B specifically in on-off phenomena

15

ADRs of D2 agonists?

nausea, hypotension, psychotic symptoms, inhibits prolactin release

16

MOA of centrally acting antimuscarinics?

inhibit dopamine storage use for early minor symptoms

17

ADRs of centrally acting antimuscarinics?

like peripheral antimuscarinics: dry mouth, constipation, urinary retention, impaired vision