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Flashcards in hypothalamus and pituitary drugs Deck (17):
1

What are the different vasopressin and oxytocin GPCRs?

V1a - PLC - vasoconstriction
V1B - PLC - ACTH release
V2 - adenylate cyclase - water reabsorption in DCT and CT
OT - PLC - inhibits adenylate cyclase

2

Uses for oxytocin

stimulates labour, treats postpartum haemorrhage, nasal spray to aid lactation

3

Uses for oxytocin receptor antagonists

premature labour

4

Uses for vasopressin and vasopressin analogues?

treat ADH deficiency e.g. diabetes insipidus

5

Uses for V-receptor antagonists

used in ADH excess, as in small cell carcinoma of the lung causing hypertension and fluid retention

6

Uses for DA receptor agonists

used to treat prolactin excess

7

ADRs of DA receptor agonists

nausea, vomiting, dizziness, postural hypotension

8

uses for somatotrophin

treat GH deficiency and manage it in children

9

ADRS of somatotrophin

muscle and joint pain, MS stiffness, local reactions, lipoatrophy, peripheral oedema and hypothyroidism

10

uses for GH releasing factor

used in diagnosing test for GH release

11

ADRs for GH releasing factor

HIV-related lipodystrophy

12

when is surgery used?

1st option for acromegaly - GH excess

13

Uses for DA receptor agonists?

treat acromegaly, works in 20% of cases (modulates GH levels - can increase or decrease GH levels)

14

uses for somatostatin analogues?

treat acromegaly, longer lasting than somatostatin

15

ADRs of somatostatin analogues?

hypothyroidism, injection site reactions, headaches, dizziness, GI upset

16

MOA of GH receptor antagonists

stops GH effects on target tissues

17

ADRs of GH receptor antagonists

injection site reactions, swollen limbs, chest pain, hypoglycaemia