Flashcards in hypothalamus and pituitary drugs Deck (17)
What are the different vasopressin and oxytocin GPCRs?
V1a - PLC - vasoconstriction
V1B - PLC - ACTH release
V2 - adenylate cyclase - water reabsorption in DCT and CT
OT - PLC - inhibits adenylate cyclase
Uses for oxytocin
stimulates labour, treats postpartum haemorrhage, nasal spray to aid lactation
Uses for oxytocin receptor antagonists
Uses for vasopressin and vasopressin analogues?
treat ADH deficiency e.g. diabetes insipidus
Uses for V-receptor antagonists
used in ADH excess, as in small cell carcinoma of the lung causing hypertension and fluid retention
Uses for DA receptor agonists
used to treat prolactin excess
ADRs of DA receptor agonists
nausea, vomiting, dizziness, postural hypotension
uses for somatotrophin
treat GH deficiency and manage it in children
ADRS of somatotrophin
muscle and joint pain, MS stiffness, local reactions, lipoatrophy, peripheral oedema and hypothyroidism
uses for GH releasing factor
used in diagnosing test for GH release
ADRs for GH releasing factor
when is surgery used?
1st option for acromegaly - GH excess
Uses for DA receptor agonists?
treat acromegaly, works in 20% of cases (modulates GH levels - can increase or decrease GH levels)
uses for somatostatin analogues?
treat acromegaly, longer lasting than somatostatin
ADRs of somatostatin analogues?
hypothyroidism, injection site reactions, headaches, dizziness, GI upset
MOA of GH receptor antagonists
stops GH effects on target tissues