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Flashcards in analgesics Deck (5):
1

mechanism of opiods

activate u receptors = GPCR coupled to K+ channels, produces membrane hyperpolarisation, inhibit VACC

2

ADRs of opioids

respiratory depression, dysphoria K-mediated, decreased gastric motility, nausea and vomiting, sedation, depression of cough reflex, pupil constriction, histamine effects as morphine causes histamine release from mast cells: hives - urticaemia, itching, bronchoconstriction, hypotension + dependence and tolerance

3

MOA of paracetamol

blocks CNS COX, therefore no anti-inflammatory action

4

ADRs of paracetamol

liver damage in overdose: antidote is N-acetylcysteine, a precursor of glutathione

5

uses of paracetamol

mild-moderate pain relief, anti-pyretic, no anti-inflammatory action