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Flashcards in thyroid and adrenal drugs Deck (19):
1

What drugs can be used to treat hyperthyroidism?

B- adrenoceptor antagonists for symptom relief
- thionamides
- iodine/iodide
- radioactive iodine

2

Effects of B-adrenoceptor antagonist?

reduce some symptoms like tachycardia, dysrhythmias, angina, tremor, agitation

3

uses of B-adrenoceptor antagonists?

hyperthyroid crisis, prepare for thyroidectomy, waiting for effects of thionamides or radioactive iodine

4

MOA of thinoamides

inhibit iodination of tyrosine on thyroglobulin, leading to decreased T3/T4 synthesis, full effects seen a few weeks later after stores are depleted

5

uses of thionamides

short term use before surgery, long-term use in Graves disease as an alternative to surgery or radioiodine

6

ADRs of thionamides

cross placenta leading to congenital hypothyroidism, rashes in 2-2.5%, headaches, nausea, jaundice, joint pain, agranulocytosis leading to fever, mouth ulcers, sore throat, rash

7

MOA of iodine

Wolff-Charikoff block: inhibit iodide organification and thyroid hormone synthesis

8

uses of iodine

short term use, ~2 weeks, preparation for thyroidectomy, thyrotoxic crisis leads to decreased vascularity and gland size

9

MOA of radioactive iodine

emits beta-particles

10

Uses of radioactive iodine

hyperthyroidism and thyroid carcinoma, TFT - oral or i.v, .

11

How long does radioactive iodine work for, how is it administered?

peak effects in 2-4 months, is an oral/single dose

12

ADRs of radioactive iodine

hypothyroidism, thyroid cancer therefore not given in pregnant people or children

13

Treatments for hypothyroidism

T4 and T3

14

when is the max effect of T4?

10 days

15

ADRS of T4

small doses in the elderly due to risk of angina, dysrhythmias, or heart failure

16

how is T3 delivered?

i.v. speed of onset e.g. in myxoedema coma

17

What drugs can cause hypothyroidism?

amiodarone - causing antidysrhythmias, iodinated contrast media.

18

What drugs are used to treat hypercortisolism and hyperaldosteronism?

aminoglutethimide (inhibits cholesterol to pregnenolone) and ketoconazole (inhibits formation of corticosterone and hydrocortisone/cortisol)

19

What drugs to treat hypocorticolism?

glucocorticoids, possible mineralocorticoid replacement therapy? + long term daily replacement therapy, additional cortisol for acute stressors