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Flashcards in Diuretics Deck (16):
1

MOA of osmotic diuretics

increase RBF, alter medullary tonicity so that tubular water reabsorption is osmotically blocked

2

Uses of osmotic diuretics (mannitol)?

localised oedema, glaucoma

3

ADRs of osmotic diuretics?

GI upset, injection site reactions, chills/fever, acute renal failure, CNS toxicity

4

MOA of CA inhibitors?

inhibit recycling of H+ secretion and Na+ reabsorption

5

Uses of CA inhibitors?

localised oedema e.g. glaucoma

6

MOA of loop/high ceiling diuretics?

acts at thick ascending limb, blocks Na+/K+/2Cl- symporter, block 15-25% of Na+ reabsorption

7

ADRs of loop diuretics

K+ wasting (dysrhythmias, ECG changes, increased digoxin toxicity, muscle weakness, constipation, drowsiness, irritability, confusion, dizziness), Na+ Mg2+ Ca2+ loss, impaired uric acid excretion, dose-related hearing loss

8

Uses of loop diuretics

APO, CHF, liver cirrhosis, renal failure, hypertension, in drug overdose, in combination with thiazides or K-sparing diuretics

9

MOA of thiazide and related diuretics?

increased Na+ excretion 5-10%, increased K+ excretion, decreased Ca2+ excretion

10

ADRs of thiazides and related diuretics?

hypokalaemia, hyperuricaemia, hypomagnesaemia, hypercholesterolaemia, hyperglycaemia, acid-base imbalance, erectile dysfunction, digoxin toxicity increased

11

K+ sparing diuretic drug groups?

aldosterone antagonists and Na+ channel blockers, act on late distal tubule and collecting ducts

12

MOA of aldosterone antagonists (spironolactone)

inhibit 3Na+/2K+ exchanger on basolateral membrane and luminal membrane Na+ channel

13

uses of aldosterone antagonists (like spironolactone)

with thiazides and loop diuretics to produce diuresis without hypokalaemia, used in conditions associated with hyperaldosteronism/Cushing's, improves survival in CHF

14

MOA of Na+ channel blockers (amiloride)

blocks Na+ channel on luminal membrane

15

Uses of Na+ channel blockers (amiloride)

to spare K+ in the absence of aldosterone, used with thiazide and loop diuretics

16

What are some drug interactions with K+ sparing drugs leading to hyperkalaemia?

- other K+ sparing diuretics
- K+ supplements
- ACE inhibitors
- AT1 receptor antagonists