Animal Welfare Flashcards Preview

Laboratory Animal Science > Animal Welfare > Flashcards

Flashcards in Animal Welfare Deck (18):
1

What can we do to implement the 3Rs?

  • Characterisation - know your animal
  • Standardisation
  • Education and training

All of this in order to minimise variation between animals

2

What is the reasoning behind laboratory animal welfare?

High quality laboratory animal science requires optimal welfare of the animals

3

What is included in the definition of animal welfare?

  • The animals are in good physiological condition and health
  • the animals are feeling well (mentally)
  • the animals can live according to their nature and perform their full range of behaviours

4

Which areas do we assess when we talk about quality of life?

  • Feelings and experiences
  • biological function
  • natural behaviour

5

Name the 5 freedoms of animal welfare

  • Freedom from hunger and thirst
  • freedom from discomfort
  • freedom from pain, injury, and disease
  • freedom from fear and distress
  • freedom to express normal behaviour

6

How do we know if the animal feels pain?

  • Similar to anatomical and physiological mechanisms to those involved in pain perception in man
  • display of behavioural response to noxious stimuli
  • response inhbited by analgesic drugs

7

Name the three levels of pain

  • pain reflex (e.g. burn your hands)
  • painful experience (you feel the pain)
  • suffering (chronic pain)

8

Which changes associated with pain can be observed in animals?

  • inactive
  • cringes
  • careless about hygiene
  • aggressive
  • "scream" when touched
  • different walking pattern
  • decreased body weight

9

How reliable are face pain scores in mice and rabbits?

  • 97% in mice
  • 82% in rabbit

10

What are the three levels of stress?

  • acute stress (positive)
  • chronic stress (negative)
  • distress

11

What is acute stress?

  • Survival mechanism
  • aid to adapt and cope
    • fight - flight - fright
  • increased activity of HPA axis and sympathetic NS
  • rapid recovery to basal level

12

What is chronic stress?

  • dystress = bad stress (greek)
  • difficulties to cope - prolonged levels of stress hormones

13

What is distress?

  • result of long-term stress
  • poor mental condition
  • boredom, frustration, anxiety, etc.
  • more difficult to define and detect in animals
  • stereotypic behaviour

14

Name some endocrine stress parameters

  • adrenal hormones (cortisol, corticosterone, adrenaline, NA)
  • pituitary hormone ACTH
  • NTs (NA)
  • opioid peptides
  • immunological markers

15

Name some physiological stress parameters

  • heart rate
  • blood pressure
  • body weight

16

Name some pathological stress parameters.

  • ulcers in GI tract
  • enlarged adrenals
  • atherosclerosis
  • lesions

17

Optimisation of Welfare in concordance with reduction

  • high quality animals
  • good quality animal facilities and husbandry
  • good experimental design

18

Optimisation of welfare in terms of refinement

  • condition animals and staff to set-up
  • use non-invasive methods when possible
  • eliminate pain
  • thorough care and monitoring
  • establish welfare protocols
  • introduce early endpoints