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Flashcards in Large animal models Deck (11):
1

Name advantages of using large animals as models

  • outbred
  • repeated blood samples possible
  • tissue biopsies
  • longer life-span
  • similar size to that of humans

2

Name disadvantages of large animal models

  • outbred
  • expensive
  • limited number of animals for practical and economical reasons
  • handling can be cumbersome

3

Where can you sample blood from pigs?

  • jugular vein
  • ear vein
  • mammary vein
  • retroorbital plexus

4

Name three different pig/swine kinds

  • Yorkshire (pointy ears standing up)
  • Hampshire (belt)
  • landrace (ears hang down)

5

Why do you use minipigs for long-term studies?

They don't grow that big

6

What are Göttingen minipigs bred from?

minnesota minipig + vietnamese pig + landrace

7

What are the 3 As in pig research?

  • Acclimatisation
  • Analgesia and Anaesthesia
  • Aseptic procedures

8

What are dogs used for in research?

  • test new pharmaceuticals
  • toxicity - non-rodent model
  • surgery - transplantation
  • insulin 1920s breakthrough
  • Gi tract
  • new vaccines for dogs
  • dentistry

9

Where are cat models used?

  • CNS
  • neurology
  • opthalmology

10

Research on primates

 

  • HIV
  • transplantation
  • ophtalmology
  • PET

11

Research areas that use rabbits

 

  • orthopedics
  • osseointegration
  • ophtalmology
  • antibody production