Antibacterials Flashcards Preview

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Flashcards in Antibacterials Deck (31)
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1

"kills"
cell wall synthesis inhibitor
Narrow

Cidals

2

"inhibits"
protein synthesis inhibitor
broad spectrum

Satics

3

inhibits transpeptidase

pinicillin

4

1st line antipseudomonals

Ceftazidime
Ciprofloxacin

5

Causes Interstitial nephritis

MEthicillin

6

Penicillinase resistant PCNs

Oxacillin
Nafcillin
Dicloxacillin

7

This is combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.

Cilastatin

8

Inhibits peptidoglycan polymerization by inhibiting D-ala Dala portion. Used for all Gram (+), for treatment of C. difficile.

Vancomycin

9

Side effect of Vancomycin

Red man syndrome

10

Drugs affecting 30s and 50s subunits

buy AT 30, CELL at 50
30s
Aminoglycosides
Tetracyclins
50s
Chloramphenicol
Erythromycin
Linezolid
cLindamycin

11

"mycin"

Animoglycosides

12

Inhibits initiation complex

Aminoglycosides

13

Inhibits amino acid incorporation

Tetracylcine

14

Inhibits peptic bond formation

Chloramphenicol

15

Inhibits translocation

Clindamycin

16

Causes destruction of Teeth and bones

"TEETHracycline"

17

Causes Aplastic Anemia and Gray baby syndrome

Chloramphenicol

18

Enzyme needed for billirubin conjugation. Lacking in babies with gray baby syndrome.

UDP glucoronyl transferase

19

Used for Typhoid, meningitis, anaerobes, rickets and brucellosis

chloramphenicol

20

alternative of penicillin allergy

erythromycin

21

a macrolide that inhibits CypP450

erythomycin

22

first line for severe anaerobic infections and aspiration pneumonia

Clindamycin

23

Inhibits DNA gyrase/tropoisomerase/ NUCLEIC ACID synthesis

Fluoroquinolones

24

fluoroquinolone drugs ends with?

"Floxacin"

25

Causes Cartilage erosion, tendon rupture(achilles tendon)

fluoroquinolone

26

Drugs responsible for inhibition of Folic acid synthesis

Sulfonamides and Trimetrhoprim

27

Sulfo+Trimethroprim =?

Cotraimoxazole

28

Treats MArrow poorly?

Trimethroprim

29

Inhibits dihydropteroate synthase

Sulfonamides, dapsone

30

Drugs that cause SJS

Sulfonamide (30%): fansider, sulfodiazine, TMP SMX
Antigoagulants: Carbamazepines, phenobarb, phenytoin