Flashcards in Katzung Antibac checklist Deck (7)
Describe the mechanism of antibacterial action of beta-lactam antibiotics.
Block tranpeptidase cross linking
Describe 3 mechanisms underlying the resistance of bacteria to beta-lactam antibiotics.
1. formation of beta-lactamases
2. Structural change in target PBPs
3. changes in the porin structures
List the major adverse effects of the penicillins and the cephalosporins.
Allergy and GI disturbances
Identify the important features of aztreonam, imipenem, and meropenem.
active against P aeruginosas.
Vancomycin MOA and Adverse effect
Gram-positive activity includes MRSA and PRSP strains
“Red-man” syndrome, rare nephrotoxicity
Bind to 30S ribosomal tigecycline has broadest spectrum and resistance is less common
GI upsets, deposition in developing bones and teeth, photosensitivity, superinfection