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Flashcards in Katzung Antibac checklist Deck (7)
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1

Describe the mechanism of antibacterial action of beta-lactam antibiotics.

Block tranpeptidase cross linking

2

Describe 3 mechanisms underlying the resistance of bacteria to beta-lactam antibiotics.

1. formation of beta-lactamases
2. Structural change in target PBPs
3. changes in the porin structures

3

List the major adverse effects of the penicillins and the cephalosporins.

Allergy and GI disturbances

4

Identify the important features of aztreonam, imipenem, and meropenem.

active against P aeruginosas.

5

Vancomycin MOA and Adverse effect

Gram-positive activity includes MRSA and PRSP strains

“Red-man” syndrome, rare nephrotoxicity

6

Bind to 30S ribosomal tigecycline has broadest spectrum and resistance is less common

GI upsets, deposition in developing bones and teeth, photosensitivity, superinfection

Tetracyclines

7

Bind to 50S ribosomal telithromycin

GI upsets, hepatic dysfunction, QT elongation
CYP450 inhibition
(not azithromycin)

Macrolides