Flashcards in Anticonvulsants Deck (14)
What is a seizure?
High frequency bursts of APs (Influx of calcium and the activation of sodium channels...or the downregulation of inhibitory neurons)q
What are the 3 MOAs of anticonvulsant drugs?
- Block the voltage gated Na channel
- Block the voltage gated Ca channel
- Potentiate GABA action
Blocking of the voltage gated Na channel does what?
Reduces the ability of the neurons to fire
Common Adverse Effects of Anticonvulsants?
suicidal ideation 1-24 weeks after starting the drug
DOC for status epilepticus?
Calcium channel blockers
Na channel blocker,,,,remember that these drugs can only inhibitactive or inactive channels. NOT deactive
Greatest risk of adverse outcomes in pregnancy>
Two drugs that potentially cause fetal hydantoin syndrome?
Phenobarbital and carbamezabine
High risk for SJS of TEN
asians with HLA-B1502