Flashcards in Anticonvulsants Deck (14):
1
What is a seizure?
High frequency bursts of APs (Influx of calcium and the activation of sodium channels...or the downregulation of inhibitory neurons)q
2
What are the 3 MOAs of anticonvulsant drugs?
- Block the voltage gated Na channel
- Block the voltage gated Ca channel
- Potentiate GABA action
3
Blocking of the voltage gated Na channel does what?
Reduces the ability of the neurons to fire
4
Common Adverse Effects of Anticonvulsants?
suicidal ideation 1-24 weeks after starting the drug
5
GABA potentiators
Clonazepem (benzodiazepine)
Phenobarbital (barbituate)
Felbamate
CPF
6
DOC for status epilepticus?
IV Lorazepem
7
Calcium channel blockers
- Ethosuxamide
- Pregabalin
- Gabapentin
8
Phenytoin MOA
Na channel blocker,,,,remember that these drugs can only inhibitactive or inactive channels. NOT deactive
9
Carbamezapine BBW
agranulocytosis
10
Greatest risk of adverse outcomes in pregnancy>
Valproate
11
Two drugs that potentially cause fetal hydantoin syndrome?
Phenobarbital and carbamezabine
12
Hirsutism?
Phenytoin
13
High risk for SJS of TEN
asians with HLA-B1502
14