Anticonvulsants Flashcards Preview

Neurology > Anticonvulsants > Flashcards

Flashcards in Anticonvulsants Deck (14):
1

What is a seizure?

High frequency bursts of APs (Influx of calcium and the activation of sodium channels...or the downregulation of inhibitory neurons)q

2

What are the 3 MOAs of anticonvulsant drugs?

- Block the voltage gated Na channel
- Block the voltage gated Ca channel
- Potentiate GABA action

3

Blocking of the voltage gated Na channel does what?

Reduces the ability of the neurons to fire

4

Common Adverse Effects of Anticonvulsants?

suicidal ideation 1-24 weeks after starting the drug

5

GABA potentiators

Clonazepem (benzodiazepine)
Phenobarbital (barbituate)
Felbamate

CPF

6

DOC for status epilepticus?

IV Lorazepem

7

Calcium channel blockers

- Ethosuxamide
- Pregabalin
- Gabapentin

8

Phenytoin MOA

Na channel blocker,,,,remember that these drugs can only inhibitactive or inactive channels. NOT deactive

9

Carbamezapine BBW

agranulocytosis

10

Greatest risk of adverse outcomes in pregnancy>

Valproate

11

Two drugs that potentially cause fetal hydantoin syndrome?

Phenobarbital and carbamezabine

12

Hirsutism?

Phenytoin

13

High risk for SJS of TEN

asians with HLA-B1502

14

What are the two drugs that don't produce SJS or TEN ever

Clonazepem and lacosamide