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Flashcards in Drugs to treat Insomnia Deck (13):
1

Barbiturates work how?

Modulate GABA receptors in the CNS.
They make GABA action last longer. At very high doses may activate GABA itself.

2

AE's of barbiturates?

increase as the dosing gets higher, duh..,,Sedation, hypnosis, anesthesia, all the way to coma....This is why they are rarely used these days

3

Benzodiazepines do what

MODULATE GABA receptors....that is, they shift the dose response curve to the left meaning less GABA creates a greater action.

4

adverse effects of benzos

sedation, cognitive impairment, rebound insomnia with short acting drugs

5

Withdrawal symptoms of benzos

anxiety, irritability, restlessness, sleep apnea, respiratory depression

6

Benzos bind what subunit of the GABA receptor

alpha

7

# different subgroups of binding sites for Benzos on the alpha subunit of GABA receptor

BZ1- sedation/amnesia

BZ2- anxiolysis

BZ3- myorelaxation/anticonvulsant

8

All benzos are ultimately eliminated how?

conjugated and then renally excreted

9

Know the benzo drugs

ok

10

Benzodiazepine receptor agonists can be used during pregnancy,,, they are cat c

ok

11

Flumazenil

Benzo antagonist. Reversal of sedation from benzo/benzo agonists. IV quick acting. causes abrupt awakening. Can cause seizure and withdrawl in chronic benzo users. Does not reverse sedation.

12

What does melatonin do

affects teh suprachiasmatic nucleus activity

13

Of the three melatonin receptors, which affect the sleep/wake cycle

MT-1 and 2