Brain Tumor Chemo Flashcards Preview

Neurology > Brain Tumor Chemo > Flashcards

Flashcards in Brain Tumor Chemo Deck (16):
1

Brain metasteses outnumber primary neoplasms by

10:1

2

Most common sites for brain mets to come from

Lung, Breast, Unknown, Melanoma

3

80% of mets go where

hemispheres

4

Management of mets may include more than just anti-tumor treatment

Also managed with steroids to control edema and anticonvulsants for seizures

5

tx of brain mets

Surgery is the mainstay since the BBB is a major issue for traditional chemo

6

Resistance to chemotherapy by the tumor cell may be assisted by communication with astrocytes that lead to upregulation of tumor genes that promote survival and more specifically lower tumor cell apoptosis. The protein products of these genes protect tumor cells from chemo

ok

7

Temozolamide mech

Pro-drug, DNA methylating agent

Labeled for astrocytoma and GBM, Off label for malignant melanoma and glioma

8

AE of temozolomide

myelosuppresion, leukopenia, thrombocytopenia,

Teratogen- CAT X

9

Temozolomide used for

Astrocytoma/ GBM

10

Resistance to Temozolomide

Upregulation of 06- MGMT which repairs the damage done by the methylator

11

Nitrosoureas- mustines

DNA alkylators, high cross resistance with other alkylators, highly lipophilic so CROSS BBB EASY

12

AEsof the mustines

myelosuppresion, N/V, PULM FIBROSIS, endocrine dysfunction, encephalopathy

13

Carmustine

parenteral

14

Lomustine

oral...malignant glioma

15

Which of the mustines not only alkylates but also carbamoylates

Carmustine

16

chemo fog may be from

High TNF-Alpha which may damage mitochondria