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Flashcards in Polyoma Virus Deck (18):
1

Polyoma virus family

papovaviridae

2

morphology of polyoma virus

circular ds DNA genome of 5-8 kbp
non-enveloped icosahedral capsule

3

polyoma viruses, as with papilloma viruses, can transform non-permissive cells and lead to tumor formation

ok

4

In permissive cells, polyoma viruses

replication and assembly of progeny occurs in the nucleus.

virions are released by cell lysis

5

In non-permissive cells

infection leads to transformation. polyoma virus genome integrates into host chromosomes

6

Describe the three T antigens of the polyoma virus

They are needed to initiate DNA replication

7

Small T and Large T antigens are necessary for what

to immortalize cells

8

Small T and Middle T needed to

transform cells....
The path goes primary cell, immortalized cell, transformed cell (these types of cells grow uninhibited by growth factors)

9

Two known human polyoma viruses

BK and JC

10

KNow that BK and JC are basically found in all humans but are NOT oncogenic

ok

11

Initial replication of BK and JC occurs where

site of infection, resp or GI tract

12

After initial infection by BK or JC, what happens

viremia and passage to kidney lung and brain

The virus persistently affects the kidney

13

BK and JC are only problematic in who?

Immunodeficient hosts

14

JC is the causative agent of

Progressive multifocal Leukoencephalopathy

15

PML is what

Progressive multifocal Leukoencephalopathy

a demyelinating disease of the CNS.
Probably due to reactivated JC virus which makes its way to the cns and infects/lyses oligodendrocytes

16

PML symptoms

clumsiness, speech problems, progressive weakness all in a matter of weeks

17

Diagnosis of PML

PCR amplification of JC virus DNA from CSF or brain biopsy
White matter lesions by MRI

18

treatment of PML

in transplant pts: alter suppression therapy

in aids pts: effective HAART treatment