Inhalational Anesthetics Flashcards Preview

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Flashcards in Inhalational Anesthetics Deck (14):
1

Analgesia

pain relief but no altered mental state

2

Anxiolysis

Decreased apprehension with no change in awareness

3

Conscious sedation

Protective reflexes maintained, Can still breathe independently. Responds to stimulation

4

Deep Sedation

Profound effects with the loss of one or more functions mintained in conscious sedation

5

General Anesthesia

Sensory/Mental/Reflex/Motor Blockade. Loss of all protective reflexes

6

General Anesthetics are

Drugs that produce reversible depression of neuronal function with loss of ability to perceive pain/sensation. Must maintain the pts airway. Frequently requires mechanical ventillation

7

MAC

Minimum alveolar concentration: minimum concentration required to anesthetize 50% of pts

8

How does MAC relate to oil:gas partition coefficient

Oil:gas partition coefficient is a measurement of lipophillicity. As the oil gas partition coef goes up, lipophillicity also goes up. The more lipophilic something is, the lower its MAC. Lower MAC means lower dosing

9

Meyer Overton hypothesis

ANesthetic action is directly linked to drug lipophilicity. Turns out this is way too simple because in some drugs, high lipophillicity means that they are inactive

10

Know that inhaled drugs potentiate or inhibit lots of different receptors.

They Increase the action of GABA, Glycine, pore K channels

They decrease the action of NMDA

Ultimately leads to less cortical interaction and the frontal cortex decreasing signaling to posterior brain areas

11

Memory goes first, then awareness, then movement in response to pain, finally autonomics, Pt may not be able to respond to pain but may still fell it

ok

12

Drugs with a low blood: gas partition will have a much faster onset of action and they also decrease in action more quickly.

ok

13

Anesthesia effects on RR

Anesthesia leads to High resp rate but with a low tidal volume....therefor high CO2. Regular shallow breathing.

14

CV effects of all but N2O

Lower BP and CO. Directly lowers SNS