Antidepressants Flashcards

0
Q

Tricyclic depressants

A

Desipramine, Amitryptiline, Nortryptiline, IMIPRAMINE, Clomipramine
(-amine, -tyline)

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1
Q

Brain amines that serve as neurotransmitters of mood

A

Norepinephrine and Serotonin

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2
Q

TCA MOA

A

Block NE and 5HT transport

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3
Q

TCA overdose

A

Coma, Convulsion, Cardiotoxicity

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4
Q

Antidepressant with sympathomimetic side effects

A

TCA

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5
Q

TCA toxic dose

A

7 mg/kg

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6
Q

TCA lethal dose

A

15 mg/kg

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7
Q

ECG findings of cardiotoxic TCA

A

Prolonged QRS

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8
Q

Reverses TCA cardiotoxicity

A

Bicarbonate

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9
Q

Major Depresseive Disorder DOC

A

Fluoxetine

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10
Q

SSRI

A

Sertraline, Citalopram, Escitalopram, Paroxetine, FLUOXETINE, Fluvoxamine
(SER PRAMiSS, di gagana ang PARecoxib sa FLU)

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11
Q

SSRI + MAO-B inihibitor

A

Serotonin syndrome

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12
Q

SSRI MOA

A

Inhibits neuronal reuptake of serotonin

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13
Q

SNRI MOA

A

inhibits neuronal reuptake of NE and serotonin

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14
Q

Antidepressant that causes erectile dysfunction

A

SSRI

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15
Q

SNRI

A

VENLAFAXINE, Desvenlafaxine, Duloxetine

fax sa dulo ng SNr

16
Q

Serotonin antagonist

A

Trazodone, Nefazodone

17
Q

Trazodone MOA

A

Blocks 5HT2 receptor

18
Q

Antidepressant causing priapism

A

Trazodone and Bupropion

19
Q

Tetracyclic antidepressant

A

Amoxapine, Mirtazapine, Bupropion

20
Q

Amoxapine MOA

A

NE reuptake inhibitor&raquo_space; Serotonin reuptake inhibitor

Blocks Dopamine D2 receptor

21
Q

Antidepressant that lowers seizure threshold

A

Amoxapine and Bupropion

22
Q

Mirtazapine

A

Presynaptic Alpha 2 adrenoreceptor antagonist

Serotonin 5 HT2 blocker

23
Q

Antidepressant causing appetite stimulation

A

Mirtazapine

24
Bupropion MOA
Inhibit reuptake of dopamine and norepinephrine, increasing its activity
25
Antidepressant given for smoking cessation
Bupropion
26
MAO inhibitor MOA
Inhibit MAO A and B | Increase CNS norepinephrine and serotonin
27
MAO inhibitors
Phenelzine, Selegiline, Tranylcypromine
28
MAO inhibitor + tyramine (cheese)
Hypertensive crisis
29
Serotonin syndrome treatment
Cyproheptadine
30
Serotonin Syndrome
Fever, Agitation, Tremors, Clonus, Hyperreflexia, Diaphoresi
31
Malignant Hyperthermia
Fever, Acidosis, Rhabdomyolysis, Trismus, Clonus, Hypertension
32
Neuroleptic Malignant Syndrome
Fever, Encehalopathy, Vitals unstable, Elevated CPK, Rigidity