Chemotherapeutics Flashcards Preview

Pharmacology > Chemotherapeutics > Flashcards

Flashcards in Chemotherapeutics Deck (62):
0

Cell cycle non-specific drug action

Tumor stem cells traversing cell cycle and at resting phase (G0)

1

Cell cycle specific drug action

Tumor stem cells traversing cell cycle only

2

G0 phase chemotherapeutic agents

Alkylating agents, Antibiotics, Antitumor, Nitrosurea (Lomustine, Carmustine, Cisplatin)

3

M phase chemotherapeutic agents

Vincristine
Vinblastine
Paclitaxel

4

G2 phase chemotherapeutic agents

Bleomycin

5

S phase chemotherapeutic agents

6-thioguanine, 6-mercaptopurine
Cytarabine, Hydroxyurea
Etoposide, Methotrexate

6

All trans retinoic acid

Acute promyelogenous leukemia

7

Acute Lymphocytic Leukemia

Methotrexate, Vincristine, ASPARAGINASE, Prednisone

8

Acute Myelogenous Leukemia

Cytarabine Rubicin

9

Breast Carcinoma

Cytotoxic agent, Tamoxifen, Anastrazole, Trastuzamab

10

Chronic Myelogenous Leukemia

Imatinib, Busulfan, Interferon

11

Colon Carcinoma

Fluorouracil, Oxaliplatin, Leucovorin

12

Hodgkin's Lymphoma

ABVD Regimen: Doxorubicin, Bleomycin, Vincristine, Dacarbazine + Prednisone

13

Non-Hodgkin's Lymphoma

CHOP Regimen: Cyclophosphamide, Doxorubicin, Vincristine, Prednisone + Rituximab

14

Ovarian Carcinoma

Carboplatin + Paclitaxel

15

Pancreatic Carcinoma

Gemticabine + Erlotinib

16

Prostate Carcinoma

Ganirelix or
Leuprolide + Flutamide

17

Lung Carcinoma

Paclitaxel, Bevacizumab, Carboplatin

18

Testicular Carcinoma

PEB Regimen: Bleomycin, Etoposide, Cisplatin (Platinol)

19

Cyclophosphamide rescue therapy

MESNA

20

Methotrexate rescue therapy

Leucovorin / Folinic acid

21

Doxorubicin rescue therapy

Dexrazoxane

22

Cisplatin rescue therapy

Amifostine

23

Side effect of cyclophosphamide

Hemorrhagic cystitis

24

Side effect of cisplatin and carboplatin

Nephrotoxicity and acoustic nerve damage

25

Decreases nephrotoxicity with cisplatin and carboplatin

Mannitol

26

Leukemogenic alkylating agent

Procarbazine

27

Side effect of dacarbazine

Phototoxicity

28

Non-leukemogenic version of procarbazine

Dacarbazine

29

Bone-marrow sparing chemotherapeutic drug

Busulfan

30

Highly lipophilic chemotherapeutic drug targeting brain tumors

Carmustine

31

Thymine-less cell death by inhibiting thymidylate synthase

5 Fluorouracil

32

Chemotherapeutic drug activated by HGPRT

6 Mercaptopurine

33

Drugs that inhibit 6 Mercaptopurine activity

Allopurinol and Febuxostat

34

Inhibits ribonucleotide reductase inhibiting DNA synthesis and repair

Cytarabine

35

CML in blast crisis - chloroma

Cytarabine

36

Vinca alkaloid causing paralytic ileus

Vincristine

37

Prevente microtubule disassembly

Paclitaxel

38

Prevents microtubule assembly

Vinca alkaloids

39

Podophyllotoxin

Etoposide

40

Inhibits DNA topoisomerase II and mitochondrial ETC

Etoposide

41

Topotecan MOA

Inhibits Topoisomerase I

42

Metastatic colorectal cancer

Irinotecan

43

Paclitaxel hematologic side effects

Neutropenia, Thrombocytopenia

44

Camptothecin

Topotecan

45

Antitumor causing irreversible dilated cardiomyopathy

Doxorubicin

46

Anthracycline

Doxorubicin

47

Bleomycin MOA

Generates free radicals

48

Antibiotic Antitumor targets what malignancy

Wilm's, Rhabdomyosarcoma (Actinomycin D)

49

GIST anticancer drug

Imatinib

50

Metastatic breast cancer

Trastuzamab

51

Targets her2/neu receptors of breast cancer cells

Trastuzamab

52

Block VEGF binding to VEGFR to lessen vascular permeability
High vascular flow and drug delivery

Bevacizumab

53

Induces complement mediated tumor lysis, direct cytotoxicity and apoptosis

Rituximab

54

Side effect of asparaginase

Acute pancreatitis

55

Differentiation therapy

All trans retinoic acid

56

Side effect of all trans retinoic acid therapy

Retinoic acid syndrome (tx dexamethasone)

57

Glucocorticoid triggering apoptosis and act on non-dividing cancer cells

Prednisone

58

Tamoxifen-resistant breast cancer

Anastrozole

59

Decadron side effect

Puffy face

60

Chemotherapeutic drugs that cause marked myelosuppression

5FU, 6MP, Methotrexate

61

Vincristine side effect

Peripheral neuropathy