Bone and Mineral Hemostasis Flashcards Preview

Pharmacology > Bone and Mineral Hemostasis > Flashcards

Flashcards in Bone and Mineral Hemostasis Deck (31):
1

Regulates Parathyroid Hormone

Ionized Calcium

2

PTH on intestine

Increase Vit D metabolite

3

PTH on kidney

Decrease calcium excretion
Increase phosphate excretion

4

High dose PTH on bone

Increase calcium and phospate reabsorption

5

Low intermittent dose PTH on bone

Bone formation

6

Vit D metabolite on intestine

Increase calcium absorption
Increase phosphate absorption

7

Vit D metabolite on kidney

Increase urinary calcium

8

Direct effect of Vit D metabolite on bone

Increase calcium reabsorption
Increase phosphate reabsorption

9

Indirect effect of Vit D metabolite on bone

Mineralization

10

Net serum effect of PTH

Increase Calcium
Decrease Phosphate

11

Net serum effect of Vit D metabolite

Increase Calcium
Increase Phosphate

12

Recombinant PTH

Teriparatide

13

PTH stimulation of osteoblast cause formation of what gland that stimulates osteoclast

RANK Ligand (RANKL)

14

Osteoclast and Osteoblast activity

Bone turnover

15

Inactive Vit D Metabolite

Ergocalciferol, Cholecalciferol

16

Active form of Vit D

1, 25 - Dihydroxycholecalciferol

17

Active Vit D Metabolite

Calcitriol, Doxecalciferol, Paricalcitol, Calcipotriene

18

Vitamin D Deficiency DOC

Inactive Vit D Metabolite

19

DOC for Hypoparathyroidism and Hyperparathyroidism in CKD and Liver disease

Active Vit D Metabolite

20

Released by the Parafollicular C cells in the thyroid gland

Calcitonin

21

Calcitonin MOA

Inhibit renal reabsorption and bone resorption
Decrease serum phosphate and calcium

22

Calcitonin SimD

Salcatonin

23

Tumor marker for Medullary thyroid Ca

Salcatonin

24

Route of administration of Calcitonin

Nasal spray

25

Indications for Calcitonin and Bisphosphonate

Paget's disease of the bone
Hypercalcemia
Osteoporosis

26

Bisphosphonate

Alendronate (-dronate, -dronic)

27

Bisphosphonate MOA

Suppress activity of osteoclast inhibit bone resorption

28

Side effect of Bisphosphonate

Esophagitis (100%)
Jaw osteonecrosis
Renal impairment

29

Phosphate binding resin

Sevelamer

30

Sevelamer MOA

binds with dietary phosphate and prevent its absoprtion
reduce uric acid level

31

Vit D Intoxication DOC

Phosphate binding resin